不同输注方式对特利加压素安全性及疗效的影响:当前的争议  

Effect of different infusion approaches on safety and efficacy of terlipressin:Current controversies

作　　者：何勇 柴璐 陈菡 祁兴顺 Yong He;Lu Chai;Han Chen;Xing-Shun Qi(Department of Gastroenter-ology,General Hospital of Northern Theater Command,Shenyang 110840,Liaoning Province,China;Graduate School of Shenyang Pharmaceutical University,Shenyang 110016,Liaoning Province,China;Department of Pharmacy,General Hospital of Northern Theater Command,Shenyang 110840,Liaoning Province,China)

机构地区：[1]北部战区总医院消化内科,辽宁省沈阳市110840 [2]沈阳药科大学研究生院,辽宁省沈阳市110016 [3]北部战区总医院药剂科,辽宁省沈阳市110840

出　　处：《世界华人消化杂志》2023年第17期705-710,共6页World Chinese Journal of Digestology

摘　　要：特利加压素是血管加压素的一种人工合成类似物,已被广泛用于治疗急性静脉曲张破裂出血及肝肾综合征等肝硬化并发症.然而,特利加压素的不同输注方式可能会造成其疗效和安全性有所差异.既往研究证明持续输注特利加压素比间歇静脉推注更有效且不良事件发生率更低.本文着重回顾相关文献并总结特利加压素不同输注方式之间疗效和安全性的差异,以指导临床实践.Terlipressin,a synthetic analog of vasopressin,has been widely used to treat acute variceal bleeding,hepatorenal syndrome,and other complications of cirrhosis.However,among different infusion approaches of terlipressin,its safety and efficacy are also heterogeneous.Previous studies have demonstrated that continuous infusion of terlipressin is more effective with a lower incidence of adverse events than intermittent intravenous infusion.This paper aims to review the relevant literature and summarize the data regarding the safety and effectiveness of different infusion approaches of terlipressin to guide clinical practice.

关 键 词：特利加压素 静脉输注 肝硬化 急性静脉曲张破裂出血 肝肾综合征 难治性腹水 感染性休克 

分 类 号：R575.2[医药卫生—消化系统] R692[医药卫生—内科学] R-03[医药卫生—临床医学]