Duodenal neuroendocrine tumor-tertiary care centre experience:A case report  

Duodenal neuroendocrine tumor-tertiary care centre experience:A case

作　　者：Uma Devi Malladi Suraj Kumar Chimata Ramesh Kumar Bhashyakarla Sahitya Reddy Lingampally Vikas Reddy Venkannagari Zeeshan Ali Mohammed Rahul Vijay Vargiya 

机构地区：[1]Department of Medical Gastroenterology,Osmania General Hospital,Telangana,Hyderabad 500012,India

出　　处：《World Journal of Translational Medicine》2023年第1期1-8,共8页世界转化医学杂志

摘　　要：BACKGROUND Neuroendocrine neoplasms(NENs)are a heterogeneous group of neoplasms arising from neuroendocrine cells,which contribute a small fraction of gastrointestinal malignancies.Duodenal neuroendocrine tumors(dNETs)represent 2%of all gastroenteropancreatic NENs.NENs are heterogeneous in terms of clinical symptoms,location,and prognosis.Non-functional NETs are mostly asymptomatic and need a high degree of clinical suspicion.Diagnosis of NETs is by endoscopic,endosonographic biopsy,and histopathological examination with immunohistochemistry staining for synaptophysin and chromogranin A.CASE SUMMARY We present case reports of 5 patients obtained over a period of 10 years in our center with dNETs.One patient had moderately differentiated NET and the remaining four had well-differentiated NET.Surveillance endoscopy was recommended in all the patients and is kept under regular follow-up after performing endoscopic therapy using endoscopic mucosal resection in 4 of them and one patient was advised to undergo a Whipple procedure.CONCLUSION Recently,the number of reported cases of NETs has increased due to advancements in diagnostic modalities and prevalence because of longer survival duration.The management differs based on the site,size,proliferation grade,and locally invasive pattern.They are slow-growing tumors with a good overall prognosis.The prognosis correlates with local lymph node status and metastasis.

关 键 词：Chromogranin A Endoscopic mucosal resection-endoscopic submucosal resection Endoscopic submucosal dissection Ki-67 protein Peptide receptor radionuclide Malladi UD et al.Duodenal neuroendocrine tumor 

分 类 号：R73[医药卫生—肿瘤]