Endoscopic Ruler for varix size measurement:A multicenter pilot study  

作　　者：Yi-Fei Huang Sheng-Juan Hu Yang Bu Yi-Ling Li Yan-Hong Deng Jian-Ping Hu Shao-Qi Yang Qian Shen Mark McAlindon Rui-Chun Shi Xiao-Qin Li Tie-Ying Song Hai-Long Qi Tai-Wei Jiao Meng-Yuan Liu Fang He Jun Zhu Bin Ma Xiao-Bin Yu Jian-Yang Guo Yue-Hua Yu Hai-Jiang Yong Wen-Tun Yao Ting Ye Hua Wang Wen-Fu Dong Jian-Guo Liu Qiang Wei Jing Tian Xiao-Guo Li Xavier Dray Xiao-Long Qi 

机构地区：[1]Institute of Portal Hypertension,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China [2]Department of Gastroenterology,People's Hospital of Ningxia Hui Autonomous Region,Ningxia Medical University Affiliated People's Hospital of Autonomous Region,Yinchuan 750000,Ningxia Hui Autonomous Region,China [3]Department of Gastroenterology,The First Affiliated Hospital of China Medical University,Shenyang 110000,Liaoning Province,China [4]Department of Gastroenterology,Yinchuan First People's Hospital,Yinchuan 750000,Ningxia Hui Autonomous Region,China [5]Department of Gastroenterology,Ningxia Medical University General Hospital,Yinchuan 750000,Ningxia Hui Autonomous Region,China [6]Department of Gastroenterology,Yinchuan Second People's Hospital,Yinchuan 750000,Ningxia Hui Autonomous Region,China [7]Academic Department of Gastroenterology and Hepatology,Sheffield Teaching Hospitals NHS Trust,AL 35660,Sheffield,United Kingdom [8]Department of Gastroenterology,Wuzhong People's Hospital,Wuzhong 751100,Ningxia Hui Autonomous Region,China [9]Department of Gastroenterology,The Fifth People's Hospital of Ningxia Hui Autonomous Region,Shizuishan 753000,Ningxia Hui Autonomous Region,China [10]Department of Second Gastroenterology,The Sixth People’s Hospital of Shenyang,Shenyang 110000,Liaoning Province,China [11]Department of Gastroenterology,Shizuishan Second People's Hospital,Shizuishan 753000,Ningxia Hui Autonomous Region,China [12]Department of Gastroenterology,Zhongwei People's Hospital,Zhongwei 755000,Ningxia Hui Autonomous Region,China [13]Department of Hepato-Gastroenterology,ETIS,ENSEA,CNRS,Sorbonne Université&APHP,Hôpital Saint Antoine,UniversitéParis-Seine,Universitéde Cergy-Pontoise,Paris 75012,Sélectionner,France [14]Center of Portal Hypertension,Department of Radiology,Zhongda Hospital,Medical School,Southeast University,Nanjing 210000,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Endoscopy》2023年第9期564-573,共10页世界胃肠内镜杂志（英文版）（电子版）

基　　金：This study is registered at https://www.clinicaltrials.gov/.The registration identification number is NCT04639323.

摘　　要：BACKGROUND We invented Endoscopic Ruler,a new endoscopic device to measure the size of varices in patients with cirrhosis and portal hypertension.AIM To assess the feasibility and safety of Endoscopic Ruler,and evaluate the agreement on identifying large oesophageal varices(OV)between Endoscopic Ruler and the endoscopists,as well as the interobserver agreement on diagnosing large OV using Endoscopic Ruler.METHODS We prospectively and consecutively enrolled patients with cirrhosis from 11 hospitals,all of whom got esophagogastroduodenoscopy(EGD)with Endoscopic Ruler.The primary study outcome was a successful measurement of the size of varices using Endoscopic Ruler.The secondary outcomes included adverse events,operation time,the agreement of identifying large OV between the objective measurement of Endoscopic Ruler and the empirical reading of endoscopists,together with the interobserver agreement on diagnosing large OV by Endoscopic Ruler.RESULTS From November 2020 to April 2022,a total of 120 eligible patients with cirrhosis were recruited and all of them underwent EGD examinations with Endoscopic Ruler successfully without any adverse event.The median operation time of Endoscopic Ruler was 3.00 min[interquartile range(IQR):3.00 min].The kappa value between Endoscopic Ruler and the endoscopists while detecting large OV was 0.52,demonstrating a moderate agreement.The kappa value for diagnosing large OV using Endoscopic Ruler among the six independent observers was 0.77,demonstrating a substantial agreement.CONCLUSION The data demonstrates that Endoscopic Ruler is feasible and safe for measuring the size of varices in patients with cirrhosis and portal hypertension.Endoscopic Ruler is potential to promote the clinical practice of the two-grade classification system of OV.

关 键 词：Oesophageal varices CIRRHOSIS Portal hypertension ESOPHAGOGASTRODUODENOSCOPY Endoscopic ruler 

分 类 号：R563.1[医药卫生—呼吸系统]