Acute hemolytic anemia in a 34-year-old man after inhalation of a volatile nitrite “popper” product  

作　　者：Xiang Peng Liuyang Cheng Huanhuan Gong Jie Wang Xiaowei Ke Xiangmin Li 

机构地区：[1]Department of Emergency Medicine,Xiangya Hospital,Central South University,Changsha 410008,China [2]National Clinical Research Center for Geriatric Disorders(Xiangya Hospital),Changsha 410008,China

出　　处：《World Journal of Emergency Medicine》2023年第5期414-415,共2页世界急诊医学杂志（英文）

基　　金：supported by a grant from Natural Science Foundation of Hunan Province (2022JJ30938)。

摘　　要：Inhaled nitrites have been used recreationally for centuries,particularly among men who have sex with men (MSM).^([1])After inhalation,this substance quickly enters the blood;within seconds,it can produce a temporary sense of warmth and pleasure,and relax the anal sphincter to relieve the pain of anal sex.^([2,3])“Popper”and“rush”are slang terms given to drugs of the chemical class called amyl nitrite or isobutyl nitrite.Nitrites oxidize hemoglobin to methemoglobins and may increase proteolytic susceptibility of hemoglobin,leading to oxidative hemolysis.Thus,their use is associated with methemoglobinemia and hemolytic anemia,^([4])although nitrite-induced hemolytic anemia has been described only in rare cases (supplementary Table 1).^([4-9])Herein,we report a case of acute hemolytic anemia associated with the use of amyl nitrite.

关 键 词：NITRITE VOLATILE OXIDATIVE 

分 类 号：R749.64[医药卫生—神经病学与精神病学]