Role of adjunctive nonpharmacological strategies for treatment of rapid-cycling bipolar disorder  

作　　者：Subho Chakrabarti Amal J Jolly Pranshu Singh Nidhi Yadhav 

机构地区：[1]Department of Psychiatry,Postgraduate Institute of Medical Education and Research,Chandigarh 160012,Chandigarh UT,India [2]Department of Psychiatry,Black Country Healthcare NHS Foundation Trust,Dudley DY28PS,West Midlands,United Kingdom [3]Department of Psychiatry,All India Institute of Medical Sciences,Jodhpur 342005,Rajasthan,India

出　　处：《World Journal of Psychiatry》2023年第8期495-510,共16页世界精神病学杂志

摘　　要：Rapid-cycling bipolar disorder(RCBD)is a phase of bipolar disorder defined by the presence of≥4 mood episodes in a year.It is a common phenomenon characterized by greater severity,a predominance of depression,higher levels of disability,and poorer overall outcomes.It is resistant to treatment by conventional pharmacotherapy.The existing literature underlines the scarcity of evidence and the gaps in knowledge about the optimal treatment strategies for RCBD.However,most reviews have considered only pharmacological treatment options for RCBD.Given the treatment-refractory nature of RCBD,nonpharmacological interventions could augment medications but have not been adequately examined.This review carried out an updated and comprehensive search for evidence regarding the role of nonpharmacological therapies as adjuncts to medications in RCBD.We identified 83 reviews and meta-analyses concerning the treatment of RCBD.Additionally,we found 42 reports on adjunctive nonpharmacological treatments in RCBD.Most of the evidence favoured concomitant electroconvulsive therapy as an acute and maintenance treatment.There was preliminary evidence to suggest that chronotherapeutic treatments can provide better outcomes when combined with medications.The research on adjunctive psychotherapy was particularly scarce but suggested that psychoeducation,cognitive behavioural therapy,family interventions,and supportive psychotherapy may be helpful.The overall quality of evidence was poor and suffered from several methodological shortcomings.There is a need for more methodologically sound research in this area,although clinicians can use the existing evidence to select and individualize nonpharmacological treatment options for better management of RCBD.Patient summaries are included to highlight some of the issues concerning the implementation of adjunctive nonpharmacological treatments.

关 键 词：Rapid-cycling bipolar disorder Bipolar disorder Adjunctive therapy Nonpharmacological treatment 

分 类 号：R749.4[医药卫生—神经病学与精神病学]