Role of gastrointestinal health in managing children with autism spectrum disorder  

作　　者：Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Rawan Alhawamdeh 

机构地区：[1]Pediatric Department,Faculty of Medicine,Tanta University,Algharbia,Tanta 31511,Egypt [2]Pediatrics,Univeristy Medical Center,King Abdulla Medical City,Arabian Gulf University,Dr.Sulaiman Al Habib Medical Group,Manama,Manama 26671,Bahrain [3]Medical Microbiology Section,Pathology Department,Salmaniya Medical Complex,Ministry of Health,Manama,Manama 12,Bahrain [4]Medical Microbiology Section,Pathology Department,Irish Royal College of Surgeon,Bahrain,Muharraq,Busaiteen 15503,Bahrain [5]Pulmonology Department,Faculty of Medicine,Tanta University,Algharbia,Tanta 31527,Egypt [6]Pulmonology Department,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Dr.Sulaiman Al Habib Medical Group,Manama,Manama 26671,Bahrain [7]Medicine,The Royal College of Surgeons in Ireland-Bahrain,Muharraq,Busiateen 15503,Bahrain [8]Pediatrics Research,and Development Department,Genomics Creativity and Play Center,Manama,Manama 0000,Bahrain [9]Pediatrics Research,and Development Department,SENSORYME Dubai 999041,United Arab Emirates

出　　处：《World Journal of Clinical Pediatrics》2023年第4期171-196,共26页世界临床儿科杂志

摘　　要：Children with autism spectrum disorders(ASD)or autism are more prone to gastrointestinal(GI)disorders than the general population.These disorders can significantly affect their health,learning,and development due to various factors such as genetics,environment,and behavior.The causes of GI disorders in children with ASD can include gut dysbiosis,immune dysfunction,food sensitivities,digestive enzyme deficiencies,and sensory processing differences.Many studies suggest that numerous children with ASD experience GI problems,and effective management is crucial.Diagnosing autism is typically done through genetic,neurological,functional,and behavioral assessments and observations,while GI tests are not consistently reliable.Some GI tests may increase the risk of developing ASD or exacerbating symptoms.Addressing GI issues in individuals with ASD can improve their overall well-being,leading to better behavior,cognitive function,and educational abilities.Proper management can improve digestion,nutrient absorption,and appetite by relieving physical discomfort and pain.Alleviating GI symptoms can improve sleep patterns,increase energy levels,and contribute to a general sense of well-being,ultimately leading to a better quality of life for the individual and improved family dynamics.The primary goal of GI interventions is to improve nutritional status,reduce symptom severity,promote a balanced mood,and increase patient independence.

关 键 词：Gastrointestinal disorders Autism spectrum disorders Children Gut microbiota Ketogenic diet Gluten-free casein-free diet Dietary management 

分 类 号：R57[医药卫生—消化系统]