p53与线粒体动力学的相互作用及其在癌症治疗中的应用  

The interaction of p53 with mitochondrial dynamics and its application in cancer therapy

作　　者：张忠文 王芙蓉[4] 赵瑞 李有鹏 杨钰婷 白金霞 张浩令 王薇 Zhang Zhongwen;Wang Furong;Zhao Rui;Li Youpeng;Yang Yuting;Bai Jinxia;Zhang Haoling;Wang Wei(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Acupuncture-Moxibustion and Tuina,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Pathology,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Gastroenterology,Minqin County People's Hospital of Gansu Province,Minqin 733300,Gansu,China;Advanced Medical and Dental Institute,University Sains Malaysia,Bertam 13200,Malaysia)

机构地区：[1]甘肃中医药大学公共卫生学院,甘肃兰州730000 [2]甘肃中医药大学中医临床学院,甘肃兰州730000 [3]甘肃中医药大学针灸推拿学院,甘肃兰州730000 [4]兰州大学第二医院病理科,甘肃兰州730030 [5]甘肃省民勤县人民医院消化内科,甘肃民勤733300 [6]马来西亚理科大学高级医学与牙科研究所,槟城马来西亚13200

出　　处：《兰州大学学报（医学版）》2023年第7期89-94,共6页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省高等学校创新基金资助项目(2023A-088);甘肃省自然科学基金资助项目(22JR5RA582,21JR1RA267);甘肃省中医药研究中心专项开放课题资助项目(zyzx-2020-zx10);甘肃省教育科技创新资助项目(2022A-067)。

摘　　要：p53蛋白是癌细胞代谢过程和代谢重编程的关键调节因子,在细胞死亡和存活之间保持平衡。线粒体动力学与细胞周期、免疫、凋亡和线粒体质量控制等许多细胞过程密切相关。p53和线粒体动力学之间存在复杂的相互作用,二者相互调节和相互影响,在细胞生理和病理过程中具有重要意义。本研究综述p53和线粒体动力学之间的相互作用机制及其在癌症中的作用,探讨相关调控机制的治疗策略。通过揭示细胞代谢和癌症发生机制,旨在为癌症治疗提供新的思路和方法。Objective The tumor suppressor protein p53 plays a pivotal role in regulating metabolic processes and metabolic reprogramming in cancer cells,striking a delicate balance between cell death and survival.Mitochondrial dynamics plays a critical role in various cellular processes,including cell cycle,immunity,apoptosis and mitochondrial quality control.This investigation unveiled a complex interplay between p53 and mitochondrial dynamics,highlighting their mutual regulation and profound influence on the physiological and pathological processes within cells.The study centered around elucidating the intricate interplay between p53 and mitochondrial dynamics,emphasizing their pivotal role in the realm of cancer.Furthermore,the research delved into the therapeutic modalities targeting these entities,with the overarching objective of unraveling the underlying mechanisms governing cellular metabolism and oncogenesis.By so doing,it endeavors to present innovative insights into and approaches to advancing the landscape of cancer treatment.

关 键 词：P53蛋白 线粒体动力学 癌症治疗 治疗策略 

分 类 号：R737.9[医药卫生—肿瘤]