Synthesis of(R)-(−)-Muscone from(R)-5-Bromo-4-methylpentanoate:A Chiron Approach  

作　　者：Junwei Shen Yong Shi Weisheng Tian 

机构地区：[1]CAS Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2015年第6期683-687,共5页中国化学（英文版）

摘　　要：A synthesis of(R)-muscone(1),a valuable musk odorant,is presented.The stereogenic center of muscone was introduced from methyl(R)-5-bromo-4-methylpentanoate(5),a chiral pool molecule developed in our group,and the macrocyclic ring was prepared by ring-closing metathesis(RCM)reaction.

关 键 词：MUSCONE FRAGRANCES macrocycles chiral pool (R)-5-bromo-4-methylpentanoate 

分 类 号：O62[理学—有机化学]