Objective:The clinical treatment of brain diseases is urgent. Xingnaojing (XNJ) injection is often used in combination with other injection drugs. Due to the possible interaction between the injections in vivo, the pa...
A synthesis of(R)-muscone(1),a valuable musk odorant,is presented.The stereogenic center of muscone was introduced from methyl(R)-5-bromo-4-methylpentanoate(5),a chiral pool molecule developed in our group,and the mac...
Objective To investigate the effect of muscone on cardiovascular system.Methods Experimental animals to divide muscone high、middle、low dose group(the mouse is 20 mg·kg-1,10 mg·kg-1,5.0 mg·kg-1;the rat is 10 mg·k...
This study was supported by the fund of "Hundred Persons Project" of Shan ghai Public Health Bureau (No. 97BR016)
Objective: To investigate muscone's neuroprotective action and it s mechanism in rats with acute cerebral ischemic injury. Methods: Rat focal ischemic model of middle cerebral artery occlusion(MCAO) was establi shed b...
the National Natural Science Foundation of China (Grant No. 29872032) ; the Provincial Natural Science Foundation of Shaanxi Province (Grant No. FF982134).
Muscone is a precious fragrant compound scarce in nature. Many attempts have been made to synthesize this unique natural product. In this work, the one-carbon unit transfer reaction of tetrahydrofolate coenzyme was in...
By ketal formation with chiral glycols like methyl or ethyl ester of tartaric acid,hydrogenation of ketals from the correspondingα,β-unsaturated 15-membered cyclic ketone produces (R)-muscone in good chemical and op...
M. Stoll's total synthetic route for dl-muscone was improved. 2.15.Hexadecanedione was synthesized by PTC method and converted into dehydromuscones through intramolecular aldol reaction by the mixture of zinc chloride...