Asymmetric Hydrosilylation of Aromatic Ketones Catalyzed by an Economical and Effective Copper-Diphosphine Catalytic System in Air  

作　　者：Minting Liang Xiaofeng Xia Xiang Liu Hexing Li 

机构地区：[1]Key Laboratory of Food Colloids and Biotechnology,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China [2]Key Laboratory of the Chinese Ministry of Education in Resource Chemistry,Shanghai Normal University,Shanghai 200234,China

出　　处：《Chinese Journal of Chemistry》2015年第5期578-582,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(No.21402066);the Open Project of the Key Laboratory of the Chinese Ministry of Education in Resource Chemistry.

摘　　要：In the presence of the inexpensive and non-toxic polymethylhydrosiloxane, the combination of copper(II) acetateand a chiral diphosphine displayed high catalytic efficiency in the asymmetric hydrosilylation of a series ofaromatic ketones in air atmosphere and at room temperature. (R)-1-Arylethanols were obtained with up to 99%yield and 93% enantiomeric excess. Meanwhile, the electron effect and steric hindrance of substituents on the aromaticring had an interesting influence on both the yields and enantioselectivities. Furthermore, a possible mechanismwas presented to explain the influence of some key factors on the reaction.

关 键 词：asymmetric catalysis HYDROSILYLATION KETONES copper salt POLYMETHYLHYDROSILOXANE 

分 类 号：O62[理学—有机化学]