Effect of pesticides on phosphorylation of tau protein,and its influence on Alzheimer’s disease  

作　　者：Erandis D Torres-Sánchez Genaro G Ortiz Emmanuel Reyes-Uribe Juan H Torres-Jasso Joel Salazar-Flores 

机构地区：[1]Department of Medical and Life Sciences,University Center of la Cienega,University of Guadalajara,Ocotlan 47820,Jalisco,Mexico [2]Department of Philosophical and Methodological Disciplines and Service of Molecular Biology in Medicine Hospital Civil,University of Guadalajara,Guadalajara 44340,Jalisco,Mexico [3]Department of Biological Sciences,CUCOSTA,University of Guadalajara,Puerto Vallarta 48280,Jalisco,Mexico

出　　处：《World Journal of Clinical Cases》2023年第24期5628-5642,共15页世界临床病例杂志

摘　　要：Alzheimer’s disease(AD)is a progressive and neurodegenerative illness which results in alterations in cognitive development.It is characterized by loss/dysfunction of cholinergic neurons,and formation of amyloid plaques,and formation of neurofibrillary tangles,among other changes,due to hyperphosphorylation of tau-protein.Exposure to pesticides in humans occurs frequently due to contact with contaminated food,water,or particles.Organochlorines,organophosphates,carbamates,pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive impairment.The aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein,and its cognitive implications in the development of AD.It was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198,Ser199,Ser202,Thr205,Ser396 and Ser404.Contact with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta,and protein phosphatase-2A.Moreover,it altered the expression of the microtubule associated protein tau gene,and changed levels of intracellular calcium.These changes affected tau protein phosphorylation and neuroinflammation,and also increased oxidative stress.In addition,the exposed subjects had poor level of performance in tests that involved evaluation of novelty,as test on verbal,non-verbal,spatial memory,attention,and problem-solving skills.

关 键 词：ORGANOCHLORINES Organophosphates CARBAMATES PYRETHROIDS NEONICOTINOIDS Tau protein 

分 类 号：R749.16[医药卫生—神经病学与精神病学]