Focal lymphoblastic transformation of chronic myelogenous leukemia develops into erythroid leukemia:A case report  

作　　者：Wei Wang Ya-Ling Chen Pan-Pan Gou Pei-Lin Wu Kun-Sheng Shan Dong-Liang Zhang 

机构地区：[1]Department of Hematology,The 909th Hospital of PLA(Southeast Hospital Affiliated to Xiamen University),Zhangzhou 363000,Fujian Province,China [2]Department of Hematology,The 175th Hospital of PLA(Southeast Hospital Affiliated to Xiamen University),Zhangzhou 363000,Fujian Province,China

出　　处：《World Journal of Clinical Cases》2023年第24期5780-5788,共9页世界临床病例杂志

基　　金：Supported by Nanjing Military Region Innovation Project,No.15MS108;and the Youth Nursery Fund,No.18Y024.

摘　　要：BACKGROUND We present a case of focal lymphoblastic transformation to erythroid leukemia following acute myeloblastic transformation in a patient with chronic myelogenous leukemia(CML)and discuss its mechanism of occurrence and development.CASE SUMMARY The presence of the Philadelphia(Ph)chromosome was identified through karyotype analysis,while the BCR-ABL fusion gene was detected using quantitative real-time polymerase chain reaction of the peripheral blood sample.Fluorescence in situ hybridization was used to detect the expression of the BCRABL gene in the lymphoma.Antigen expression and gene mutations in the primitive cells were detected by flow cytometry.The analysis confirmed the presence of CML along with focal lymphoblastic transformation to erythroid leukemia.Additionally,the patient was found to have secondary erythroid leukemia,along with multiple new gene mutations and abnormalities in complex karyotypes of chromosomes.CONCLUSION Our findings suggest a possible molecular basis for the focal lymphoblastic transformation secondary to myeloblastic transformation in patients with CML.

关 键 词：Chronic myelogenous leukemia Blast crisis Focal lymphoblastic transformation Pure erythroid leukemia Case report 

分 类 号：R733.71[医药卫生—肿瘤]