Aggressive variant prostate cancer:A case report and literature review  

作　　者：Xiang-Tao Weng Wen-Li Lin Qi-Man Pan Tao-Fen Chen Si-Yi Li Chi-Ming Gu 

机构地区：[1]Department of Urology,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong Province,China [2]Department of Urology,The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2023年第26期6213-6222,共10页世界临床病例杂志

基　　金：Guangdong Provincial Hospital of Traditional Chinese Medicine,NO 2022KT1166 and NO 2018KT1635;Guangdong Provincial Bureau of Traditional Chinese Medicine,NO 2021KT1500;Guangzhou Science and Technology Bureau,NO 202201020350.

摘　　要：BACKGROUND Aggressive variant prostate cancer(AVPC)is a rare disease that progresses rapidly.The first-line treatment for AVPC is currently unknown.We examined a rare case of AVPC with rare brain and bladder metastases.A summary review of the mechanism of development,clinicopathological manifestations,associated treatments and prognosis of this disease is presented.CASE SUMMARY The patient was diagnosed with prostate cancer(PCA),and was actively treated with endocrine therapy,radiotherapy,chemotherapy,and traditional Chinese medicine.Unfortunately,he was insensitive to treatment,and the disease progressed rapidly.He died five years after being diagnosed with PCA.CONCLUSION We should reach consensus definitions of the AVPC and other androgen receptorindependent subtypes of PCA and develop new biomarkers to identify groups of high-risk variants.It is crucial to complete a puncture biopsy of the tumor or metastatic lesion as soon as possible in patients with advanced PCA who exhibit clinical features such as low Prostate-specific antigen levels,high carcinoembryonic antigen levels,and insensitivity to hormones to determine the pathological histological type and to create a more aggressive monitoring and treatment regimens.

关 键 词：Aggressive variant prostate cancer Prostate-specific antigen Carcinoembryonic antigen Prostate cancer 

分 类 号：R735.9[医药卫生—肿瘤]