Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology:A case report and literature review  

作　　者：Meng Jiang Xiao-Ping Yuan 

机构地区：[1]School of Medicine,Sun Yat-sen University,Shenzhen 518107,Guangdong Province,China [2]Department of Radiology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2023年第26期6289-6297,共9页世界临床病例杂志

基　　金：National College Students Innovation and Entrepreneurship Training Program,No.202110558154;College Students Innovation and Entrepreneurship Training Program of Sun Yat-sen University,No.202211534;and No.202311516.

摘　　要：BACKGROUND Collision tumors of primary malignant lymphoma and adenocarcinoma in the colon are rare.Primary diffuse large B-cell lymphoma(DLBCL)–adenocarcinoma collision tumors are especially rare.CASE SUMMARY A 74-year-old woman presented with abdominal pain of 1 mo duration.Biopsy under colonoscopy revealed adenocarcinoma of the ascending colon.Subsequently,the patient underwent laparoscopic radical resection of right colon cancer with lymph node dissection.A collision tumor was found incidentally through postoperative pathological sampling.Genetic analysis showed a collision tumor of DLBCL with germinal center B-cell subtype and TP53 mutation,and adenocarcinoma arising in a tubulovillous adenoma in the colon,with BRAF mutation and mutL homolog 1 promoter methylation.The patient died 3 mo after surgery.To our knowledge,this is the 23rd reported case of collision tumor of colorectal adenocarcinoma and lymphoma.The mean age of the 23 patients was 73 years.The most common site was the cecum.There were 15 cases with followup data including 11 living and four dead with a 3-year overall survival rate of 71.5%.CONCLUSION Based on pathological and genetic analysis,surgery combined with chemotherapy or chemoradiotherapy may have good therapeutic effects for collision tumor.

关 键 词：Collision tumor Colorectal adenocarcinoma Primary colonic lymphoma Molecular pathological analysis Case report 

分 类 号：R735[医药卫生—肿瘤]