Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression  

作　　者：Daniel Mateus de Oliveira Batista Jessica Manoelli Costa da Silva Carolina de Oliveira Gigek Marilia de Arruda Cardoso Smith Paulo Pimentel de Assumpcao Danielle Queiroz Calcagno 

机构地区：[1]Nucleo de Pesquisas em Oncologia,Universidade Federal do Para,Belem 66073-000,Para,Brazil [2]Departamento de Patologia,Universidade Federal de São Paulo,Sao Paulo 04023-062,São Paulo,Brazil [3]Disciplina de Genetica,Departamento de Morfologia e Genetica,Universidade Federal de São Paulo,São Paulo 04023-900,Sao Paulo,Brazil

出　　处：《World Journal of Gastrointestinal Oncology》2023年第9期1520-1530,共11页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Gastric cancer(GC)remains among the most common cancers worldwide with a high mortality-to-incidence ratio.Accumulated evidence suggests that long noncoding RNAs(lncRNAs)are involved in gastric carcinogenesis.These transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels,inducing or inhibiting biological processes and diseases.Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)is one of the best-studied lncRNAs with comprehensive actions contributing to cancer progression.This lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and proteins.In the present review,we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in GC.Moreover,we highlighted the potential use of MALAT1 as a biomarker,including liquid biopsy.

关 键 词：Long noncoding RNA Gastric carcinogenesis Transcriptional levels Posttranscriptional levels Prognostic biomarker Liquid biopsy 

分 类 号：R735.34[医药卫生—肿瘤]