Use of induced pluripotent stem cell-derived brain cells,organoids,assembloids,and blood-brain barrier models in understanding alcohol and anesthetic-induced brain injuries:an emerging perspective  

作　　者：Xiaowen Bai 

机构地区：[1]Department of Cell Biology,Neurobiology&Anatomy,Medical College of Wisconsin,Milwaukee,WI,USA

出　　处：《Neural Regeneration Research》2024年第5期953-954,共2页中国神经再生研究（英文版）

基　　金：supported by grants R01 GM112696 and 1R35GM148177 from the National Institutes of Health(to XB);Advancing a Healthier Wisconsin(to XB);Medical College of Wisconsin-Neuroscience Research Center-Alzheimer’s Award(to XB).

摘　　要：Neurological disorders,including developmental disorders,Alzheimer’s disease(AD),and psychiatric conditions,have significant social and economic impacts globally.Despite extensive research into the underlying mechanisms of these disorders,effective treatments remain elusive,partly due to the complexity of the brain,the limited availability of human brain tissue,and the blood-brain barrier(BBB)’s impermeability to certain drugs.This perspective article discusses the potential of human induced pluripotent stem cell(iPSC)-based models of brain cells,organoids,assembloids,and BBB to advance our understanding of the etiology,progression,and mechanisms of brain injuries induced by alcohol consumption and general anesthesia.These models could also be used to develop protective and therapeutic approaches.

关 键 词：INJURIES protective DRUGS 

分 类 号：R651.15[医药卫生—外科学]