眼针联合运动功能训练治疗缺血性脑卒中临床观察  

Clinical Observation of Rehabilitation with Eye-Acupuncture Combined with Motor Function Training in the Treatment of Ischemic Stroke Hemiplegia

作　　者：王开欣 孙雪平 罗涛[2] 张攀 王丹 魏从兵 WANG Kaixin;SUN Xueping;LUO Tao;ZHANG Pan;WANG Dan;WEI Congbing(The Affiliated Hospital of China University of Geocsciences,Wuhan 430074,Hubei,China;Wuhan Central Hospital,Wuhan 430074,Hubei,China)

机构地区：[1]中国地质大学(武汉)医院,湖北武汉430074 [2]华中科技大学同济医学院附属武汉市中心医院,湖北武汉430074

出　　处：《辽宁中医药大学学报》2023年第8期158-162,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：武汉市卫计委科研立项项目(XG202005070060)。

摘　　要：目的探讨眼针联合运动功能训练对缺血性脑卒中偏瘫患者康复的影响。方法选择130例缺血性脑卒中偏瘫患者随机分为观察组和对照组,每组65例。对照组采用运动功能训练,观察组采用眼针联合运动功能训练,连续治疗4周。治疗前、治疗4周时,观察两组患者的临床疗效、中风病症状和体征积分、美国国立卫生研究院卒中量表(NIHSS)评分、Fugl-Meyer运动功能评定量表(FMA)评分、Berg平衡量表(BBS)评分、改良Barthel指数评定量表(MBI)评分,比较两组患者的高迁移率族蛋白B1(HMGB1)、C1q肿瘤坏死因子相关蛋白9(CTRP9)、钙调素(CAM)水平。结果(1)观察组临床有效率优于对照组(P<0.05);(2)治疗后,两组患者的中风病症状和体征积分、NIHSS评分、FMA评分、BBS评分、MBI评分较治疗前均显著改善,且观察组改善程度明显优于对照组(P<0.05);(3)治疗后,两组患者的血清HMGB1、CTRP9、CAM水平较治疗前均显著改善,且观察组改善程度明显优于对照组(P<0.05)。结论眼针联合运动功能训练治疗缺血性脑卒中偏瘫,能够有效减轻患者神经损伤,提高患者运动功能、平衡功能和日常生活能力,缓解患者症状,临床疗效显著,其作用机制可能与促进血清CTRP9表达水平、抑制血清HMGB1和CAM水平有关。Objective To investigate the efficacy of rehabilitation with eye-acupuncture combined with motor function training in patients with ischemic stroke hemiplegia.Methods 130 patients with ischemic stroke hemiplegia were randomly divided into observation group and control group.There were 65 cases in each group.The control group was treated with motor function training,and the observation group was treated with rehabilitation with eye-acupuncture combined with motor function training,the treatment lasting 4 continuous weeks.After 4 weeks of treatment,the clinical efficacy,stroke symptoms and signs score,national institute of health stroke scale(NIHSS),Fugl-Meyer assessment(FMA)score,Berg balance scale(BBS)score,modified Barthel index(MBI)score in the two groups were evaluated,and serum levels of high mobility group protein B1(HMGB1),C1q and tumor necrosis factor related protein 9(CTRP9),calmodulin(CAM)in the two groups were detected.Results(1)The clinical effective rate of the observation group was superior to that of the control group(P<0.05);(2)After treatment,stroke symptoms and signs score,NIHSS score,FMA score,BBS score and MBI score of the two groups were significantly improved,and the improvement degree of the observation group were significantly superior to that of the control group(P<0.05);(3)After treatment,the levels of serum HMGB1,CTRP9 and CAM of the two groups were significantly improved,and the improvement degree of the observation group were significantly superior to that of the control group(P<0.05).Conclusion Rehabilitation with eye-acupuncture combined with motor function training in the treatment of ischemic stroke hemiplegia can effectively alleviate patients'symptoms,improve patients'motor function,balance function and ability of daily living,and reduce patients'nerve injury.Its mechanism may be related to promoting the level of CTRP9 and inhibiting the levels of HMGB1 and CAM.

关 键 词：缺血性脑卒中 偏瘫 眼针 运动功能训练 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]