RP%、CD64、PCT、SAA、ACTA对急性白血病患者化疗后感染的预测价值  

Predictive value of RP%,CD64,PCT,SAA and ACTA in post-chemotherapy infection in patients with acute leukemia

作　　者：伍昕玥 赵沙沙[1] 范芙蓉 倪苏娇 崔尖 WU Xin-yue;ZHAO Sha-sha;FAN Fu-rong;NI Su-jiao;CUI Jian(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610032,China;不详)

机构地区：[1]成都中医药大学附属医院检验科,四川成都610032 [2]四川省肿瘤医院检验科,四川成都610042 [3]陕西省结核病防治院检验科,陕西西安710110

出　　处：《中华医院感染学杂志》2023年第15期2295-2299,共5页Chinese Journal of Nosocomiology

基　　金：四川省科研基金资助项目(2021LD569)。

摘　　要：目的 分析外网织血小板百分比(RP%)、白细胞抗原分化群64(CD64)、降钙素原(PCT)、淀粉样蛋白A(SAA)、激活素-A(ACTA)水平对急性白血病患者化疗后感染的预测价值。方法 回顾性收集2019年1月-2022年6月成都中医药大学附属医院收治的109例急性白血病化疗后患者临床资料作为白血病组,根据患者化疗后是否发生感染将其分为感染组(67例)和未感染组(42例),同时根据感染组预后情况将其分为预后良好组(36例)和预后不良组(31例);选取同期在医院接受体检的116名健康体检者体检资料作为健康对照组。统计白血病组和健康对照组外周血RP%、CD64及血清PCT、SAA、ACTA水平,比较白血病组有无感染患者和不同预后患者外周血RP%、CD64及血清PCT、SAA、ACTA水平。结果 白血病组外周血RP%、CD64及血清PCT、SAA、ACTA水平高于健康对照组(P<0.05);感染组外周血RP%、CD64及血清PCT、SAA、ACTA水平高于未感染组(P<0.05);联合检测敏感度、AUC值高于外周血RP%、CD64、血清PCT、SAA、ACTA(P<0.05);预后不良组外周血RP%、CD64及血清PCT、SAA、ACTA水平高于预后良好组(P<0.05)。结论 外周血RP%、CD64及血清PCT、SAA、ACTA水平联合对急性白血病患者化疗后感染的发生具有较好的预测价值,同时不同预后急性白血病化疗后感染患者上述指标水平存在差异。OBJECTIVE To analyzed the predictive value of levels of network platelet percentage(RP%),leukocyte antigen differentiation group 64(CD64)and procalcitonin(PCT),amyloid A(SAA)and activin-A(ACTA)in post-chemotherapy infection in patients with acute leukemia.METHODS Clinical data of 109 patients with acute leukemia after chemotherapy admitted to the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from Jan 2019 to Jun 2022 were retrospectively enrolled as the leukemia group.All patients were divided into the infected group(67 cases)and uninfected group(42 cases)according to whether post-chemotherapy infection occurred.The infection group was sub-divided into the good prognosis group(36 cases)and bad prognosis group(31 cases).The data of physical examination in l16 healthy volunteers in our hospital during the same period were collected and divided into the healthy control group.The levels of RP%and CD64 in peripheral blood and serum PCT,SAA and ACTA in the leukemia group and the healthy control group were detected,and the indexes in the leukemia group were compared between patients with and without infection,and among patients with different prognosis.RESULTS The levels of RP%,CD64 in the peripheral blood and serum PCT,SAA and ACTA in the leukemia group were higher than those in the healthy control group(P<o.05).The indexes in the infected group were higher than those in the uninfected group(P<0.05).Sensitivity and AUC value of combined detection of peripheral blood RP%,CD64,serum PCT,SAA and ACTA were higher than those of the individual detections(P<0.05).The levels of RP%,CD64 in the peripheral blood and serum PCT,SAA and ACTA in the bad prognosis group were higher than those in the good prognosis group(P<0.05).CONCLUSION Levels of RP%,CD64 in the peripheral blood and serum PCT,SAA and ACTA have good predictive value for the occurrence of infection after chemotherapy in patients with acute leukemia.Meanwhile,there were differences in levels of RP%,CD64,PCT,SAA and ACTA among different prog

关 键 词：急性白血病 化疗 感染 网织血小板 白细胞抗原分化群64 降钙素原 淀粉样蛋白A 激活素-A 预测价值 

分 类 号：R733.71[医药卫生—肿瘤]