基于肾藏精理论探讨大补元煎对难治性癫痫患者免疫功能以及认知功能的影响  

Influence of Dabuyuan Decoction(大补元煎)on Immune Function and Cognitive Function of Patients with Refractory Epilepsy Based on Theory of“Kidney Storing Essence”

作　　者：韩帅[1] 刘姿瑶[2] 张小倩[1] 阎丽媚 HAN Shuai;LIU Ziyao;ZHANG Xiaoqian;YAN Limei(The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2023年第7期94-98,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目项目(81801053)。

摘　　要：目的基于“肾藏精”理论探讨大补元煎对难治性癫痫患者的免疫功能以及认知功能的影响。方法纳入2019年3月—2021年3月收治的难治性癫痫患者104例,随机分两组,对照组采用常规治疗联合认知康复训练;在此基础上,观察组采用基于“肾藏精”理论的大补元煎治疗,持续干预3个月。比较两组的临床疗效及不良反应,治疗前后测定血清CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)和Addenbrooke评估量表(ACE-Ⅲ)。结果对照组的有效率80.77%(42/52)低于观察组94.23%(49/52),差异有统计学意义(P<0.05)。观察组治疗后血清CD_(3)^(+)、CD_(4)^(+)及CD_(4)^(+)/CD_(8)^(+)均高于对照组,CD_(8)^(+)低于对照组,差异有统计学意义(P<0.05)。观察组治疗后注意、记忆力、语言流利、视空间评分均高于对照组,有统计学意义(P<0.05)。两组总不良反应率分析,差异无统计学意义(P>0.05)。结论基于“肾藏精”理论的大补元煎可以进一步提高难治性癫痫的治疗效果,改善免疫功能和认知功能,且安全性高。Objective Based on the theory of“kidney storing essence”,this paper discussed the influence of Dabuyuan Decoction(大补元煎)on immune function and cognitive function of patients with refractory epilepsy.Methods A total of 104 patients with intractable epilepsy from March 2019 to March 2021 were randomly divided into two groups.The control group received cognitive rehabilitation training.On this basis,the observation group was treated with Dabuyuan Decoction based on the theory of“kidney storing essence”,and the intervention lasted for 3 months.The clinical efficacy and adverse reactions were compared between the two groups.Serum CD_(3)^(+),CD_(4)^(+),CD+8,CD_(4)^(+)/CD+8 and Addenbrooke Assessment Scale(ACE-Ⅲ)were measured before and after treatment.Results The effective rate of the control group[80.77%(42/52)]was lower than that[94.23%(49/52)]of the study group,with statistical significance(P<0.05).After treatment,serum CD_(3)^(+),CD_(4)^(+) and CD_(4)^(+)/CD+8 in the study group were higher than those of the control group,while CD+8 was lower than that of the control group,with statistical significance(P<0.05).After treatment,the scores of attention,memory,language fluency and visual space in the study group were higher than those of the control group,with statistical significance(P<0.05).The total adverse reaction rate of the two groups was not statistically significant(P>0.05).Conclusion Dabuyuan Decoction combined with cognitive rehabilitation training based on the theory of“kidney storing essence”can further improve the therapeutic effect of refractory epilepsy,immune function and cognitive function,and has high safety.

关 键 词：“肾藏精”理论 大补元煎 认知康复训练 难治性癫痫 免疫功能 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]