m^(6)A RNA甲基化与皮肤黑素瘤相关性的研究进展  

Associations between m^(6)A RNA methylation and cutaneous melanoma

作　　者：谌芳琪 梁闫 吴婷[1] 黄长征[1] Chen Fangqi;Liang Yan;Wu Ting;Huang Changzheng(Department of Dermatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《中华皮肤科杂志》2023年第9期889-892,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81972565)。

摘　　要：N6-甲基腺苷(m^(6)A)修饰可通过影响RNA的稳定性、核运输、翻译效率、剪接及降解影响基因表达。目前研究表明,m^(6)A修饰与黑素瘤的增殖、转移及免疫治疗抵抗等生物学行为相关,具体机制仍待研究。该文综述了m^(6)A RNA甲基化修饰的调控及其在黑素瘤中的生物学行为及机制。N6-methyladenosine(m^(6)A)modification can regulate gene expression by influencing RNA stability,nuclear transport,translation efficiency,alternative splicing and degradation.Current studies have shown that m^(6)A modification is associated with multiple biological behaviors of melanoma,such as proliferation,metastasis and resistance to immunotherapy,but specific mechanisms still need further study.This review summarizes the regulation of m^(6)A RNA methylation,and its related biological behaviors and mechanisms of action in melanoma.

关 键 词：黑色素瘤 RNA甲基化 N6-甲基腺苷 

分 类 号：R739.5[医药卫生—肿瘤]