基于Lasso-Logistic回归模型的老年糖尿病无症状高尿酸血症患者并发ARAS影响因素分析  

Analysis of influencing factors of asymptomatic hyperuricemia in elderly patients with diabetes complicated with ARAS based on Lasso-Logistic regression model

作　　者：孙敬 刘鑫[1] 万美琳 王晓明[1] 王迪[1] SUN Jing;LIU Xin;WAN Meilin;WANG Xiaoming;WANG Di(Department of Endocrinology,First Hospital of Qinhuangdao Qinhuangdao Hebei 066000,China)

机构地区：[1]秦皇岛市第一医院内分泌科,河北秦皇岛066000 [2]秦皇岛市第一医院手术部,河北秦皇岛066000

出　　处：《中国急救复苏与灾害医学杂志》2023年第9期1211-1214,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：秦皇岛市科技计划项目(编号:202004A087)。

摘　　要：目的调查老年糖尿病无症状高尿酸血症患者并发动脉粥样硬化性肾动脉狭窄(ARAS)情况,并探讨影响因素。方法选取秦皇岛市第一医院225例老年糖尿病无症状高尿酸血症患者,另按照相同性别、年龄标准进行1∶1配对选取单纯高尿酸血症患者225例、单纯糖尿病患者225例。比较不同患者ARAS发生情况,并分析老年糖尿病无症状高尿酸血症患者并发ARAS危险因素。结果225例老年糖尿病无症状高尿酸血症患者并发ARAS 65例,占28.89%,明显高于单纯高尿酸血症患者、单纯糖尿病患者(P<0.05);Lasso-Logistic回归分析显示,年龄、颈-股脉搏波传导速度(cf-PWV)、吸烟史、糖化血红蛋白(HbA_(1)c)、血尿酸(BUA)、糖尿病病程、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)、三酰甘油(TG)及颈动脉内中膜中层厚度(CIMT)均为老年糖尿病无症状高尿酸血症患者并发ARAS独立危险因素(P<0.05),踝肱指数(ABI)为独立保护因素(P<0.05)。结论老年糖尿病无症状高尿酸血症患者ARAS发生率高达28.89%,且影响因素众多,涉及年龄、HbA_(1)c、TG、吸烟史、UA、ABI、BMI、LDL-C、cf-PWV、糖尿病病程及CIMT,临床需加以重视。Objective To investigate the situation of atherosclerotic renal artery stenosis(ARAS)in elderly patients with asymptomatic hyperuricemia of diabetes,and to explore the influencing factors.Methods Two hundred and twenty-five elderly patients with asymptomatic hyperuricemia due to diabetes were selected from the First Hospital of Qinhuangdao City,and 225 patients with simple hyperuricemia and 225 patients with simple diabetes were selected by 1∶1 matching according to the same gender and age standards.The incidence of ARAS in different patients was compared,and the risk factors of ARAS in elderly asymptomatic hyperuricemia patients with diabetes were analyzed.Results 225 elderly patients with asymptomatic hyperuricemia of diabetes complicated with ARAS in 65 cases,accounting for 28.89%,which was significantly higher than that of simple hyperuricemia patients and simple diabetes patients,with a statistically significant difference(P<0.05).Lasso-Logistic regression analysis showed that age,carotid femoral pulse wave velocity(cf-PWV),glycosylated hemoglobin(HbA_(1)c),blood uric acid(BUA),course of diabetes,smoking history,body mass index(BMI),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C)and carotid intima-media thickness(CIMT)were all independent risk factors for asymptomatic hyperuricemia in elderly diabetes patients with ARAS(P<0.05).and the ankle brachial index(ABI)was an independent protective factor(P<0.05).Conclusion The incidence of ARAS in elderly asymptomatic hyperuricemia patients with diabetes is as high as 28.89%,and there are many influencing factors,including age,HbA_(1)c,TG,smoking history,UA,ABI,BMI,LDL-C,cf PWV,diabetes course and CIMT,which should be paid attention to clinically.

关 键 词：2型糖尿病 高尿酸血症 ARAS 影响因素 

分 类 号：R781.63[医药卫生—口腔医学]