瑞马唑仑复合舒芬太尼在无痛超声胃镜检查中的安全性  

Safety of remazolam combined with sufentanil in painless ultrasound gastroscopy

作　　者：陈海波 张毓洁 蒋柯 CHEN Haibo;ZHANG Yujie;JIANG Ke(College of Anaesthesia,Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]贵州医科大学麻醉学院,550025 [2]贵州医科大学附属医院麻醉科

出　　处：《临床麻醉学杂志》2023年第8期838-841,共4页Journal of Clinical Anesthesiology

摘　　要：目的瑞马唑仑复合舒芬太尼在无痛超声内镜检查中的安全性。方法选择2022年4—6月行无痛超声胃镜检查的患者76例,男28例,女48例,年龄18~64岁,BMI 18~30 kg/m^(2),ASAⅠ—Ⅲ级。采用随机数字表法将患者分为两组:瑞马唑仑组(R组)和丙泊酚组(P组),每组38例。静脉推注舒芬太尼0.1μg/kg,4 min后R组静脉推注瑞马唑仑0.2 mg/kg,P组静脉推注丙泊酚1.5 mg/kg,待患者改良警觉/镇静(MOAA/S)评分≤3分时进行超声胃镜操作。记录检查期间、恢复期间低血压、呼吸抑制发生情况。记录镇静时间、苏醒时间、离室时间、镇静成功例数,下镜成功例数及注射痛等不良事件发生情况。记录患者、麻醉科医师、内镜医师满意度评分。结果与P组比较,R组检查期间、恢复期间低血压发生率和呼吸抑制发生率、注射痛发生率均明显降低(P<0.05)。两组镇静时间、苏醒时间、离室时间、镇静成功率、下镜成功率、患者、麻醉科医师、内镜医师满意度评分差异均无统计学意义。结论瑞马唑仑复合舒芬太尼在无痛超声胃镜检查围术期安全性更高,血流动力学更稳定,不良反应少,镇静效果与丙泊酚类似。Objective The safety of remazolam combined with sufentanil in painless endoscopic ultrasonography.Method Seventy-six patients with painless ultrasound gastroscopy from April 2022 to June 2022,28 males and 48 females,aged 18-64 years,BMI 18-30 kg/m^(2),ASA physical statusⅠ-Ⅲ,were selected.The patients were randomly divided into two groups using random number table method:remazolam group(group R)and propofol group(group P),38 patients in each group.Sufentanil 0.1μg/kg was given intravenously,4 minutes later,remazolam 0.2 mg/kg was given intravenously in group R,and propofol 1.5 mg/kg was given intravenously in group P.When the patient's modified observer's assessment of alertness/sedation scale(MOAA/S)score≤3 points,ultrasonic gastroscopy was performed.The incidence of hypotension and respiratory depression during the examination and recovery period,the sedation time,awakening time,departure time,the incidence ofsedation success,the incidence ofendoscopic success,and the incidence of adverse events such as injection pain were recorded.The satisfaction survey scores of patients,anesthesiologists,and endoscopists were recorded.Results Compared with group P,the incidence of hypotension and respiratory depression were significantly decreased during the examination period and recovery period,and the incidence of injection pain was significantly decreased in group R(P<0.05).There were no significant differences in sedation time,awakening time,ventricular departure time,the success rate of sedation and endoscopy,satisfaction surveys scores of patients,anesthesiologists,and endoscopists between the two groups.Conclusion Remazolam combined with sufentanil used in painless ultrasonic gastroscopy is safe and stable in hemodynamics,with less adverse reactions in perioperative period,which can achieve sedative effect similar to propofol.

关 键 词：瑞马唑仑 丙泊酚 无痛超声胃镜检查 低血压 呼吸抑制 

分 类 号：R573[医药卫生—消化系统]