脆性X智力低下蛋白在皮肤黑素瘤中的表达及与血液学比值指标相关性研究  

Expression of FMRP in cutaneous malignant melanoma and its correlation with hematologic ratios

作　　者：李思锐 罗素君 蔡桂月 邹静文 文玮 任俊男 陈嵘祎 LI Sirui;LUO Sujun;CAI Guiyue;ZOU Jingwen;WEN Wei;REN Junnan;CHEN Rongyi(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091

出　　处：《皮肤性病诊疗学杂志》2023年第4期301-306,共6页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省自然科学基金(2020A1515010281)。

摘　　要：目的探讨脆性X智力低下蛋白(FMRP)在中国人群皮肤恶性黑素瘤中的表达情况及与血液学比值指标的相关性。方法收集23例中国籍皮肤恶性黑素瘤(黑素瘤组)和10例健康人正常皮肤(正常皮肤组)组织标本,采用免疫组化染色观察FMRP的表达,计算组织化学评分(H-Score)与免疫反应评分(IRS),分析FMRP与皮肤恶性黑素瘤不同病理分级、分期间的关系。收集其中18例黑素瘤患者血常规结果,分析FMRP与患者中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)、全身炎症标志物(SIM)等血液学比值指标的相关性。结果FMRP在黑素瘤组的表达水平明显高于正常皮肤组(P<0.05)。黑素瘤患者FMRP的H-Score、IRS评分与Clark分级、Breslow深度、AJCC分期无相关性(P>0.05)。黑素瘤患者FMRP的H-Score评分与MLR、SIM呈正相关,与LMR呈负相关;IRS评分与NLR呈正相关,与LMR呈负相关。结论FMRP在皮肤黑素瘤组织中高表达,与NLR、SIM及LMR显著相关。Objective To investigate the expression of fragile X mental retardation protein(FMRP)in Chinese patients with malignant melanoma and its correlation with hematologic ratios.Methods Lesional skin samples were collected from 23 Chinese with malignant melanoma(melanoma group),and skin samples from 10 normal subjects served as controls(normal skin group).The expression of FMRP was observed using immunohistochemical(IHC)staining,and two scoring methods(H-Score and IRS)were used to evaluate the expression levels.The relationship between FMRP and different pathological grades and stages of malignant melanoma was assessed.The association of FMRP with some hematological ratios,such as neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(LMR)and systemic inflammatory markers(SIM)in patients with malignant melanoma were analyzed.Results The expression levels of FMRP in the melanoma were significantly higher than that in the normal skin(P<0.05).But H-score and IRS scales were not correlated with Clark level,Breslow thickness,and melanoma stage(P>0.05).Expression levels of FMRP were positively correlated with NLR and SIM,while negatively correlated with LMR.Conclusions FMRP is highly expressed in cutaneous malignant melanoma and its expression levels are significantly correlated with NLR,SIM,and LMR.

关 键 词：皮肤肿瘤 恶性黑素瘤 脆性X智力低下蛋白 

分 类 号：R739.5[医药卫生—肿瘤]