miR-181b-5p在恶性肿瘤发生发展中的作用研究进展  

Research progress on the role of miR-181b-5p in the occurrence and development of malignant tumors

作　　者：黄俊辉(综述) 何迎春(审校)[1,2] Huang Junhui;He Yingchun(Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心、中医药防治眼耳鼻咽喉疾病湖南省重点实验室,长沙410208

出　　处：《疑难病杂志》2023年第9期1004-1008,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：基金资助项目(2022JJ30447,2023JJ40500);长沙市自然科学基金资助项目(kq2208206);湖南省中医药管理局项目(D2022105);湖南省卫健委项目(D202307017740);湖南中医药大学中医学一流学科资助项目(22JBZ011);湖南中医药大学校级课题(2022XJJJ014,2022YYZK010)。

摘　　要：微小RNA-181b-5p(miR-181b-5p)是一种高度保守的微小RNA,在人类癌症中发挥重要作用,能够与靶mRNA的3’UTR序列互补结合,调节致癌或抑癌靶基因的表达,从而调控肿瘤的增殖、凋亡、迁移、自噬和细胞周期进展。在多种癌症中,miR-181b-5p都发挥着促癌或抑癌作用,并且逐渐证实其在早期诊断、分期分级、耐药靶点、治疗靶点及预后生物标志物等方面具有应用价值。本文简要综述近年来miR-181b-5p在恶性肿瘤中的研究进展。miR-181b-5p is a highly conserved microRNA that plays an important role in human cancer.It can complement and bind with the 3'UTR sequence of target mRNA,regulate the expression of oncogenic or tumor suppressor target genes,and thus regulate tumor proliferation,apoptosis,migration,autophagy,and cell cycle progression.In various cancers,miR-181b-5p plays a promoting or inhibiting role,and it has gradually been proven to have application value in early diagnosis,staging and grading,drug resistance targets,treatment targets,and prognostic biomarkers.This article briefly reviews the research progress of miR-181b-5p in malignant tumors in recent years.

关 键 词：微小RNA-181b-5p 恶性肿瘤 机制 

分 类 号：R73[医药卫生—肿瘤]