钼靶X线特征与Her2、E-cadherin的关系及在乳腺癌腋窝淋巴结转移中的诊断效能  

Relationship between mammographic features and Her2 as well as E-cadherin and their diagnostic efficacy in axillary lymph node metastasis of breast cancer

作　　者：丁玉梅 王志刚 赖华 Ding Yumei;Wang Zhigang;Lai Hua(Chengdu Women’s and Children’s Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610073,China)

机构地区：[1]电子科技大学医学院附属妇女儿童医院•成都市妇女儿童中心医院,成都610073

出　　处：《广西医科大学学报》2023年第8期1383-1389,共7页Journal of Guangxi Medical University

基　　金：2021年成都市医学科研课题资助(No.2021030)。

摘　　要：目的:探讨钼靶X线特征与人类表皮生长因子受体2(Her2)、上皮钙黏素(E-cadherin)的关系及在乳腺癌腋窝淋巴结转移中的诊断效能。方法:选取2017年6月至2022年6月电子科技大学医学院附属妇女儿童医院收治的80例乳腺癌患者,根据手术病理结果是否存在腋窝淋巴结转移分为转移组(n=38)、无转移组(n=42),比较两组钼靶X线特征及不同特征患者的Her2、E-cadherin表达情况,多因素logistic回归分析钼靶X线特征与腋窝淋巴结转移的关系,并分析钼靶X线特征诊断效能。结果:转移组Her2表达阳性率高于无转移组,E-cadherin表达阳性率低于无转移组(P<0.05);边缘有毛刺、钙化特征、结构扭曲、淋巴结肿大、无淋巴结脂肪浸润患者Her2阳性表达率高于边缘无毛刺、无钙化、无结构扭曲、无淋巴结肿大、有淋巴结脂肪浸润患者(P<0.05);边缘有毛刺、血管增粗、增多、有钙化、结构扭曲、无淋巴结脂肪浸润患者E-cadherin表达阳性率低于边缘无毛刺,血管征象正常、无钙化、无结构扭曲、有淋巴结脂肪浸润患者(P<0.05);转移组大小≥2 cm、边缘有毛刺、血管增粗、增多、结构扭曲、淋巴结肿大患者多于无转移组,淋巴结脂肪浸润患者少于无转移组(P<0.05);多因素logistic回归分析显示,大小≥2 cm、边缘有毛刺、血管增粗、增多、结构扭曲、淋巴结肿大、淋巴结脂肪浸润均是腋窝淋巴结转移的相关影响因素(P<0.05);钼靶X线特征联合诊断腋窝淋巴结转移的敏感度、特异度、阳性预测值、阴性预测值、约登指数最高,依次为94.74%、92.86%、92.31%、95.12%、0.8760。结论:乳腺癌钼靶X线大小≥2 cm、边缘有毛刺、血管增粗、增多、结构扭曲、淋巴结肿大、淋巴结脂肪浸润征与腋窝淋巴结转移有关,且部分特征可反映Her2、E-cadherin表达情况,联合以上特征能为诊断腋窝淋巴结转移与评估Her2、E-cadherin表达提供参考,有�Objective:To investigate the relationship between mammographic features and human epidermal growth factor receptor 2(Her2)as well as E-cadherin and their diagnostic efficacy in axillary lymph node metastasis of breast cancer.Methods:80 breast cancer patients admitted to Women’s and Children’s Central Hospital,School of Medicine,University of Electronic Science and Technology of China from June 2017 to June 2022 were selected and divided into metastatic group(n=38)and non-metastatic group(n=42)according to the presence or absence of axillary lymph node metastasis on surgical pathology.The mammography features of the two groups and the expressions of Her2 and E-cadherin in patients with different features were compared,and multivariate logistic regression analysis was conducted to analyze the relationship between mammographic features and axillary lymph node metastasis,and to analyze the diagnostic efficiency of mammographic features.Results:The positive expression rate of Her2 was higher in the metastatic group than in the non-metastatic group,and the positive expression rate of E-cadherin was lower than in the non-metastatic group(P<0.05);the positive expression rate of Her2 was higher in patients with marginal burr,calcified features,structural distortion,lymph node enlargement and no lymph node fatty infiltration than in patients with no marginal burr, no calcification,no structural distortion, no lymph node enlargement and lymph node fatty infiltration (P<0.05);the positiveexpression rate of E-cadherin was lower in patients with marginal burr, thickened and increased vessels, calcification,structural distortion and no fatty infiltration of lymph nodes than in patients with no marginal burr, normalvascular signs, no calcification, no structural distortion and fatty infiltration of lymph nodes (P<0.05). In the metastaticgroup, there were more patients with ≥2 cm in size, marginal burr, thickened and increased vessels, structuraldistortion, and lymph node enlargement than in the non-metastatic group, and fe

关 键 词：钼靶X线特征 Her2 E-CADHERIN 乳腺癌 腋窝淋巴结转移 诊断效能 

分 类 号：R737.9[医药卫生—肿瘤]