宫颈癌术后盆腔复发放疗同步或序贯化疗的临床分析  

Clinical analysis of radiotherapy combined with concurrent or sequential chemotherapy for postoperative pelvis recurrence

作　　者：孙志方 钟艳 刘婷 崔欣 李秀敏 SUN Zhi-fang;ZHONG Yan;LIU Ting(Linyi Cancer Hospital,Linyi 276000,Shandong)

机构地区：[1]临沂市肿瘤医院,山东临沂276000

出　　处：《安徽医专学报》2023年第4期119-121,共3页Journal of Anhui Medical College

基　　金：山东省医药卫生科技发展计划项目(编号:202005031026);临沂市科技发展计划项目(编号:2022YX0130)。

摘　　要：目的:探讨宫颈癌术后盆腔复发患者行同步放化疗(CCRT)和序贯放化疗(SCRT)的临床疗效。方法:回顾性分析202例宫颈癌术后盆腔复发患者的临床资料,98例患者接受CCRT和104例接受SCRT。分析CCRT组和SCRT组的近期治疗疗效、无进展生存时间(PFS)、累积生存率(OS)、放疗不良反应、生活质量。结果:对两组患者进行比较,CCRT组患者比SCRT组获得更好的近期疗效。CCRT组患者的3、5年PFS率明显高于SCRT组。CCRT组患者的5年OS率明显高于SCRT组。两组患者1年PFS率差异无统计学意义(P>0.05);1、3年OS率无统计学差异。在不良反应方面,CCRT组患者骨髓抑制的发生率较SCRT组高,差异有统计学意义;两组患者急慢性放射性膀胱炎及直肠炎的发生率差异均无统计学意义。结论:CCRT比SCRT有更明确的临床治疗疗效,但血液毒性的发生率较SCRT重。Objective:This study was to compare the clinical efficacy of concurrent chemoradiotherapy(CCRT)and sequential chemoradiotherapy(SCRT)for postoperative pelvis recurrence in cervical cancer.Methods:The clinical data of 202 patients with postoperative pelvis recurrence in cervical cancer were retrospectively analyzed.98 patients were treated with CCRT and 104 were treated with SCRT.The short-term therapeutic efficacy,progression free survival(PFS),overall survival(OS),adverse reactions of radiotherapy and quality of life in the CCRT group and the SCRT group were analyzed.Results:The CCRT group had a better short-term therapeutic efficacy than the SCRT group.The PFS of 3-year and 5-year in the CCRT group were significantly higher than these in the SCRT group.The 5-year OS was significantly higher in the CCRT group than in the SCRT group.There was no significant difference in 1-year PFS between the two groups.There was no significant difference in OS between 1-year and 3-year between the two groups.In terms of adverse reactions,the incidence of bone marrow suppression was more severe in the CCRT group than in the SCRT group,and the difference was statistically significant.There was no significant difference in acute and chronic radiation cystitis and proctitis between these two groups.We used the EORTC QLQ-C30 scale to analyze the quality of life of patients in the two groups before and 4 months after treatment,and there was no statistical significance between the two groups.Conclusion:CCRT has more definite clinical therapeutic effect than SCRT,but the blood toxicity is more serious than SCRT.

关 键 词：宫颈癌 同步放化疗 调强放疗 序贯放化疗 复发 

分 类 号：R737.3[医药卫生—肿瘤]