桦褐孔菌化学成分研究  

Studies on Chemical Constituents of Inonotus obliquus

作　　者：曾文丽 罗美琪 陈玉[1] 杨光忠[2] Zeng Wenli;Luo Meiqi;Chen Yu;Yang Guangzhong(College of Chemistry and Material Sciences,South-Central Minzu University,Wuhan,Hubei 430074,China;School of Pharmaceutical Sciences,South-Central Minzu University,Wuhan,Hubei 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院,湖北武汉430074 [2]中南民族大学药学院,湖北武汉430074

出　　处：《绿色科技》2023年第12期264-270,共7页Journal of Green Science and Technology

基　　金：湖北省重点研发项目(编号:2021ACB003)。

摘　　要：为研究桦褐孔菌的化学成分,采用溶剂提取法、正反相硅胶色谱柱、半制备高效液相色谱等多种色谱技术对桦褐孔菌乙醇提取物进行分离纯化,得到了19个化合物,根据化合物的波谱数据鉴定了他们的结构,其结构分别鉴定为:白桦酯醇(1)、3β-乙酰齐墩果酸(2)、28-O-acetylbetulin(3)、betulin 3β-caffeate(4)、(2E,24S)-5a,8a-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol(5)、过氧麦角甾醇(6)、ergosta-4,6,8(14),22-tetraen-3-one(7)、(E)-4-(4'-羟基苯基)-3-丁烯-2-酮(8)、4-(3',4'-二羟基苯基)-3-丁烯-2-酮(9)、烟碱酮(10)、5,6-二羟基-1(3H)-异苯并呋喃酮(11)、对羟基苯甲醛(12)、对羟基苯乙酮(13)、丁香酸(14)、原儿茶酸(15)、没食子酸-3-甲基醚(16)、3,4-二羟基苯甲醛(17)、4-甲氧基邻苯二酚(18)、3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one(19),其中化合物(8)、(10)、(11)、(16)为首次从桦褐孔菌中分离得到。To study the chemical constituents of Inonotus obliquus,the ethanol extracts were isolated and purified by solvent extraction method,the normal and reverse phase silica gel column chromatography and semi-preparative HPLC.Nineteen compounds were isolated,and their structures were identified asbotulin(1),3β-acetyloleanolic acid(2),28-O-acetylbetulin(3),betulin 3β-caffeate(4),(2 E,24 S)-5a,8a-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol(5),5,8-epidioxy-5a,8a-ergosta-6,22 E-dien-3β-ol(6),ergosta-4,6,8(14),22-tetraen-3-one(7),(E)-4-(4'-hydroxyphenyl)-3-buten-2-one(8),4-(3',4'-dihydroxyphenyl)-3-butene-2-one(9),inotilone(10),5,6-dihydroxy-3H-2-benzofuran-1-one(11),p-hydroxybenzaldehyde(12),p-hydroxyacetophenone(13),syringic acid(14),protocatechuic acid(15),3-O-methylgallic acid(16),3,4-dihydroxybenzaldehyde(17),4-methoxycatechol.(18),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one(19).Compounds 8,10,11 and 16 were isolated from Inonotus obliquus for the first time.

关 键 词：桦褐孔菌 化学成分 五环三萜类 甾类 酚类化合物 

分 类 号：Q936[生物学—微生物学]