山茱萸中1个新的酚酸类化合物  

A new phenolic acid from Cornus officinalis

作　　者：高洪敏 彭中灿 王利杰 潘雪格 赫军[4] 张维库[3] 续洁琨 GAO Hong-min;PENG Zhong-can;WANG Li-jie;PAN Xue-ge;HE Jun;ZHANG Wei-ku;XU Jie-kun(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Clinical Medical Sciences,China-Japan Friendship Hospital,Beijing 100029,China;Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学中药学院,北京100029 [2]北京中医药大学生命科学学院,北京100029 [3]中日友好医院临床医学研究所,北京100029 [4]中日友好医院药学部,北京100029

出　　处：《中草药》2023年第16期5142-5145,共4页Chinese Traditional and Herbal Drugs

基　　金：中央高水平医院临床科研业务费(2023-NHLHCRF-CXYW-01,2022-NHLHCRF-YNZJ-01);国家自然科学基金项目(82073731,82273815,82273809);中国药学会以岭生物医药创新基金(CPA-B04-ZC-2021-005);中国医学科学研究院基本科研业务费(2022-JKCS-1616);天然药物活性物质与功能国家重点实验室开放基金(GTZK202101,GTZK202206);中日友好医院菁英计划(ZRJY2021-BJ06,ZRJY2021-TD06)。

摘　　要：目的研究山茱萸Cornus officinalis水提取物部位的化学成分。方法采用多种色谱技术进行分离纯化,通过质谱及核磁共振等方法对化合物进行结构鉴定,并以α-葡萄糖苷酶抑制活性为指标对其降糖活性进行研究。结果从山茱萸水提取物中分离得到了1个酚酸类化合物,鉴定为2-(2-乙氧基-2-氧乙基)-3,5-二羟基苯基4-羟基苯甲酸酯(1);α-葡萄糖苷酶抑制活性的半数抑制浓度(median inhibition concentration,IC50)值为7.439μmol/L。结论化合物1为新的酚酸类化合物,命名为山茱萸酸酯A,其具有较好的α-葡萄糖苷酶抑制活性。Objective To study on the constituents from water extract of Cornus officinalis.Methods The water extract of C.officinalis was separated and purified by use of various chromatographic techniques,and the structures of the isolates were elucidated by mass spectrometry and nuclear magnetic resonance.The hypoglycemic activity of the compounds using α-glucosidase inhibitory activity as index was also investigated.Results One phenolic acid compound was isolated from the extract of C.officinalis and identified as 2-(2-ethoxy-2-oxoethyl)-3,5-dihydroxyphenyl 4-hydroxybenzoate(1).The IC50 value of theα-glucosidase inhibitory activity was 7.439μmol/L.Conclusion Compound 1 is a new phenolic acid,named cornusester A,with goodα-glucosidase inhibitory activity.

关 键 词：山茱萸 酚酸类 山茱萸酸酯A α-葡萄糖苷酶抑制活性 降糖活性 

分 类 号：R284.1[医药卫生—中药学]