双相情感障碍患者外周血单个核细胞中IL-6、IL-6R水平与PSG指标的相关性  

Correlation between the levels of IL-6 and IL-6R in peripheral blood mononuclear cells and PSG indexes in patients with bipolar disorder

作　　者：杨泽峰 冯虹 潘友让 YANG Zefeng;FENG Hong;PAN Yourang(Department of Psychiatry,Shaoxing Seventh People’s Hospital,Shaoxing 312000,Zhejiang,China)

机构地区：[1]绍兴市第七人民医院精神科,浙江绍兴312000

出　　处：《中国现代医生》2023年第25期23-26,68,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2020RC131,2022RC279)。

摘　　要：目的分析双相情感障碍患者外周血单个核细胞(peripheral blood mononuclear cell,PBMC)中白细胞介素-6(interleukin-6,IL-6)、IL-6受体(IL-6 receptor,IL-6R)水平与多导睡眠监测(polysomnography,PSG)指标的相关性。方法选取2019年2月至2022年2月绍兴市第七人民医院收治的双相情感障碍患者98例纳入双相情感障碍组,将杨氏躁狂状态评定量表(Young mania rating scale,YMRS)评分≥13分且躁狂发作的51例患者纳入躁狂组,汉密尔顿抑郁量表(Hamilton depressive scale,HAMD)评分≥17分且抑郁发作的47例患者纳入抑郁组;同期选取在本院行PSG的单相情感障碍患者104例纳入对照组。检测各组患者PBMC中IL-6、IL-6R表达水平。采用Pearson法分析PBMC中IL-6、IL-6R水平及二者与呼吸暂停低通气指数(apnea-hypopnea index,AHI)、最低血氧饱和度(oxygen saturation,SO_(2))的相关性。采用Spearman法分析PBMC中IL-6、IL-6R水平与HAMD评分、YMRS评分、简易精神状态检查量表(mini-mental state examination,MMSE)评分的相关性。结果双相情感障碍组患者的IL-6、IL-6R水平及AHI显著高于对照组,最低SO_(2)显著低于对照组(P<0.05)。躁狂组患者的IL-6、IL-6R水平及AHI显著高于抑郁组,病程显著长于抑郁组,最低SO_(2)、MMSE评分显著低于抑郁组(P<0.05)。相关性分析显示,躁狂组患者的IL-6、IL-6R水平均与YMRS评分呈正相关(P<0.05);抑郁组患者的IL-6、IL-6R水平均与HAMD评分呈负相关(P<0.05);双相情感障碍组患者的IL-6与IL-6R水平呈正相关(P<0.05),IL-6、IL-6R水平均与AHI呈正相关,与最低SO_(2)、MMSE评分呈负相关(P<0.05)。结论双相情感障碍患者PBMC中的IL-6、IL-6R呈高表达,二者与AHI、SO_(2)有紧密关系。Objective To analyze the correlation between the levels of interleukin-6(IL-6)and IL-6 receptor(IL-6R)in peripheral blood mononuclear cell(PBMC)and polysomnography(PSG)indexes in patients with bipolar disorder.Methods From February 2019 to February 2022,98 patients with bipolar disorder who were admitted to Shaoxing Seventh People’s Hospital were enrolled as the research objects in bipolar disorder group.51 patients with manic episodes and Young mania rating scale(YMRS)score≥13 points were included in mania group,and 47 patients with depressive episodes and Hamilton depressive scale(HAMD)scores≥17 points were included in depression group.Meantime,104 patients with unipolar affective disorder who underwent PSG monitoring in our hospital were selected in control group.The expression levels of IL-6 and IL-6R in PBMC were detected.Pearson method was used to analyze the levels of IL-6 and IL-6R in PBMC and their correlation with apnea-hypopnea index(AHI)and minimum oxygen saturation(SO_(2)).Spearman method was used to analyze the correlation between the levels of IL-6 and IL-6R in PBMC with HAMD score,YMRS score and mini-mental state examination(MMSE)score.Results The levels of IL-6,IL-6R,and AHI in bipolar disorder group were significantly higher than those in control group,minimum SO_(2)was significantly lower than that in control group(P<0.05).The levels of IL-6,IL-6R,and AHI in manic group were significantly higher than those in depressive group,the course of disease was significantly longer than that in depression group,and minimum SO_(2)and MMSE scores were significantly lower than those in depression group(P<0.05).Correlation analysis showed that the levels of IL-6 and IL-6R in mania group were positively correlated with YMRS score(P<0.05),the levels of IL-6 and IL-6R in depression group were negatively correlated with HAMD scores(P<0.05).In bipolar disorder group,there was a positive correlation between IL-6 and IL-6R levels(P<0.05),the levels of IL-6 and IL-6R were positively correlated with AHI,but neg

关 键 词：双相情感障碍 白细胞介素-6 白细胞介素-6受体 外周血单个核细胞 

分 类 号：R749.4[医药卫生—神经病学与精神病学]