帕金森病发病机制研究进展  

Research progress on the pathogenesis of Parkinson's disease

作　　者：肖琪 樊慧杰 李艳荣 孙芮芮 贾璐 徐磊 尉杰忠[2] 肖保国[3] 马存根 柴智 Xiao Qi;Fan Hui-Jie;Li Yan-Rong;Sun Rui-Rui;Jia Lu;Xu Lei;Wei Jie-Zhong;Xiao Bao-Guo;Ma Cun-Gen;Chai Zhi(School of Basic Medical Science/Neurobiology Research Center,Shanxi University of Traditional Chinese Medicine,Jinzhong,Shanxi 030619,China;Institute of Brain Science,Shanxi Datong University,Datong,Shanxi 037009,China;Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200025,China)

机构地区：[1]山西中医药大学基础医学院/神经生物学研究中心,山西晋中030619 [2]山西大同大学脑科学研究所,山西大同037009 [3]复旦大学华山医院神经病学研究所,上海200025

出　　处：《解放军医学杂志》2023年第8期983-992,共10页Medical Journal of Chinese People's Liberation Army

基　　金：山西省青年拔尖人才支持计划项目(2019年);山西省省筹资金资助回国留学人员科研项目(2021-142);山西省晋中市科技重点研发计划(社会发展)项目(Y213004);山西中医药大学青年科学家培育计划项目(2021PY-QN-03)。

摘　　要：帕金森病是中老年人常见的神经系统慢性炎性变性疾病,以黑质中多巴胺能神经元减少和路易小体形成为主要病理基础,其常见临床表现有静止性震颤、运动迟缓、肌张力增强和姿势步态异常等。该病发病机制十分复杂,可能与年龄、环境、遗传、氧化应激及线粒体功能障碍等多种因素有关。本文综述了导致多巴胺能神经元变性的α-突触核蛋白、氧化应激、线粒体功能障碍,以及富含亮氨酸的重复激酶2(LRRK2)基因突变等因素在帕金森病发病过程中作用机制的相关研究进展,以期为帕金森病的基础和临床研究提供参考。Parkinson's disease(PD)is a common chronic inflammatory disease of the nervous system in the middle-aged and elderly.The main pathological basis of PD is the decrease of dopaminergic neurons in the substantia nigra and the formation of Louie bodies.The clinical manifestations of PD are usually quiescent tremor,bradykinesia,enhanced muscle tone and abnormal posture and gait.The pathogenesis of PD is very complex,which may be related to age,environment,heredity,oxidative stress and mitochondrial dysfunction.In this review,we summarized research progress on the mechanisms and treatment methods ofα-synuclein,oxidative stress,mitochondrial dysfunction,LRRK2 gene mutation and other factors leading to the degeneration of dopaminergic neurons in PD,in order to provide a reference for basic and clinical research of PD.

关 键 词：帕金森病 Α-突触核蛋白 线粒体功能障碍 氧化应激 LRRK2基因突变 

分 类 号：R742.5[医药卫生—神经病学与精神病学]