帕罗西汀对产后抑郁症患者神经内分泌功能及睡眠的影响  

Clinical efficacy of paroxetine on neuroendocrine function and sleep in patients with postpartum depression

作　　者：潘靖华 PAN Jinghua(Shanghai Mental Health Center,Pharmacy Department,Shanghai 200030,China)

机构地区：[1]上海市精神卫生中心药剂科,上海200030

出　　处：《国际精神病学杂志》2023年第4期783-785,792,共4页Journal Of International Psychiatry

摘　　要：目的 探讨产后抑郁症患者应用帕罗西汀治疗的临床效果及对神经内分泌和睡眠的影响.方法 2021年3月~2023年3月医院收治的产后抑郁症患者200例,按照"随机数字表法"分为对照组(予以马普替林治疗)与观察组(予以帕罗西汀治疗),各纳入100例;观察对比两组负性情绪、睡眠质量、神经内分泌功能指标、性激素水平、不良反应发生率.结果 治疗后两组爱丁堡产后抑郁量表(EPDS)评分、匹兹堡睡眠质量指数(PSQI)评分均下降,且观察组评分明显低(P<0.05);治疗后,两组血清皮质醇(Cor)、(ACTH)水平均下降,5-羟色胺(5-HT)水平均升高,其中观察组患者更优(P<0.05);治疗后,两组血清雌二醇(E2)、孕酮(P)水平均升高,催乳素(PRL)水平均下降,且观察组较对照组更显著(P<0.05);两组患者不良反应发生率比较无明显差异(P>0.05).结论 帕罗西汀用于治疗产后抑郁症患者,可发挥调控机体神经营养因子和性激素水平的作用,使患者抑郁程度得到显著改善,进一步提高其睡眠质量.Objective To explore the clinical effect of paroxetine treatment on postpartum depression and its impact on neuroendocrine and sleep.Methods From March 2021 to March 2023,200 patients with postpartum de-pression were collected and divided into a control group(treated with maprotilin)and an observation group(treated with paroxetine)based on a standardized grouping method of"Random number table method",with 100 cases included each;The negative emotions,sleep quality,neuroendocrine function indicators,sexual hormone levels,and inci-dence of adverse reactions between two groups were compared.Results After treatment,the scores of the Edinburgh Postnatal Depression Scale(EPDS)and the Pittsburgh Sleep Quality Index(PSQI)decreased in both groups,and the scores in the observation group were significantly lower(P<0.05).After treatment,the levels of serum cortisol(Cor)and adrenocorticotropic hormone(ACTH)decreased and the levels of 5-hydroxytryptamine(5-HT)increased in both groups,with patients in the observation group being better(P<0.05).After treatment,the levels of serum estradiol(E2)and progesterone(P)in both groups increased,while the levels of prolactin(PRL)decreased,and the obser-vation group was more significant than the control group(P<0.05).There no different in incidence of adverse reactions between the two groups(P>0.05).Conclusion Paroxetine can play a role in regulating the levels of neurotrophic factors and sexual hormones in patients with postpartum depression,significantly improving the degree of depression and further improving their sleep quality.

关 键 词：产后抑郁症 帕罗西汀 临床效果 神经内分泌 睡眠 

分 类 号：R749.05[医药卫生—神经病学与精神病学]