帕罗西汀对帕金森病伴抑郁患者的效果及不良反应  

The efficacy and adverse reaction of paroxetine in the treatment of Parkinson's disease patients with depression

作　　者：王丽[1] 赵梓喆 杨宁波 黄丽娜[4] WANG Li;ZHAO Zizhe;YANG Ningbo(The First Affliated Hospital of Henan University of Science and Technology,Pharmacy Department,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院药学部,洛阳471000 [2]河南科技大学基础医学与法医学院 [3]河南科技大学第一附属医院精神心理科 [4]河南科技大学第一附属医院神经内科

出　　处：《国际精神病学杂志》2023年第4期793-795,798,共4页Journal Of International Psychiatry

基　　金：河南省医学科技攻关计划联合共建立项项目(编号:LHGJ20200573)。

摘　　要：目的 探讨在帕金森病伴抑郁患者治疗的过程中,选择帕罗西汀的价值、疗效及安全性.方法 随机选择2021年1月~2022年12月在我院确诊的96例帕金森病伴抑郁患者,以入院顺序的单双数分组后每组48例,对照组纳入的患者实施常规治疗,观察组纳入的患者在对照组基础上实施盐酸帕罗西汀片治疗.统计治疗后临床疗效、不良反应发生率,并就治疗前后患者焦虑及抑郁心理状态、认知功能及改良Webster症状评分进行评价.结果 观察组48例患者经盐酸帕罗西汀片治疗后,评估显示的焦虑、抑郁结果,较对照组明显降低(P<0.05);观察组记录的临床疗效,较对照组明显升高(P<0.05);观察组记录的不良反应发生率,较对照组降低(P<0.05);观察组评估显示认知功能评分,较对照组升高(P<0.05);观察组评估显示改良Webster症状评分,较对照组降低(P<0.05).结论 在帕金森病伴抑郁患者的治疗过程中,选择帕罗西汀既可改善其焦虑、抑郁症状,同时可确保治疗有效性及安全性,缓解疾病对患者认知功能的影响.Objective To explore the value,efficacy,and safety of paroxetine hydrochloride in the treatment of patients with Parkinson's disease and depression.Methods 96 patients with Parkinson's disease and depression in our hospital from January 2021 to December 2022 were selected and divided into two groups(48 cases in each group).Pa-tients in the control group were treated with regular treatment,while patients in the observation group were treated with paroxetine on the basis of the control group.The clinical efficacy,incidence of adverse reactions,and psychological status of anxiety and depression,cognitive function,and improved Webster symptom scores were evaluated before and after treatment.Results After treatment with paroxetine,the anxiety and depression scores in the observation group were significantly lower than those in the control group(P<0.05).The clinical efficacy in the observation group was significantly higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).The cognitive function score in the observation group was higher than that in the control group(P<0.05).The evaluation of the observation group showed that the modified Webster symptom score was lower than that of the control group(P<0.05).Conclusion During the treatment of patients with Parkinson's disease and depression,selecting paroxetine can not only improve their anxiety and depression symptoms,but also ensure the effectiveness and safety of treatment,and alleviate the impact of the disease on cognitive function of patients.

关 键 词：盐酸帕罗西汀片 帕金森病 抑郁 临床效果 不良反应发生率 认知功能 

分 类 号：R749.2[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学]