囊腔型肺癌MSCT征象与TTF-1、CK5/6及P63表达的相关性研究  

Relationship between MSCT signs and TTF-1,CK5/6 and P63 expression in cystic lung cancer

作　　者：顾吾立 费芳 周冰[1] 薛超 朱鹏飞 GU Wuli;FEI Fang;ZHOU Bing;XUE Chao;ZHU Pengfei(Department of Radiology,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314000,China;Department of Radiology,Jiaxing City First Hospital,Jiaxing 314000,China;Department of Radiology,Zhejiang Provincial Cancer Hospital,Hangzhou 310000,China)

机构地区：[1]浙江省嘉兴市中医医院放射科,浙江嘉兴314000 [2]浙江省嘉兴市第一医院放射科,浙江嘉兴314000 [3]浙江省肿瘤医院放射科,浙江杭州310000

出　　处：《医学影像学杂志》2023年第8期1368-1372,1385,共6页Journal of Medical Imaging

基　　金：浙江省医药卫生科技计划项目(编号:2021KY1123)。

摘　　要：目的探讨囊腔型肺癌(Cystic lung cancer,CLC)的MSCT征象与TTF-1、CK5/6及P63表达之间的相关性,以期在肿瘤病变的早期通过CT检查推测其生物学行为,改善CLC患者的预后。方法选取并分析35例经病理证实的CLC患者的临床病理和影像学资料,采用统计学分析CLC的MSCT征象与病理亚型、TTF-1、CK5/6及P63的相关性。结果囊腔型鳞癌组患者的平均年龄(60.5±7.8)岁最高,浸润性腺癌组(53.0±10.3)岁次之,原位及微浸润腺癌组(40.9±11.0)岁最低。原位及微浸润腺癌全部出现磨玻璃征(100%);鳞癌组出现分叶(83.3%)、壁结节(83.3%)的比例最高;浸润性腺癌组出现分隔征象(81.8%)的比例最高。CLC的血管集束征、磨玻璃征与TTF-1阳性表达具有相关性;分叶征与CK5/6的阳性表达具有相关性;Mascalchi分型Ⅰ型、分叶、壁结节征象与P63的阳性表达相关。结论可以通过CLC的患者年龄、Mascalchi分型、分叶、壁结节、磨玻璃征、血管集束征,来提示其病理亚型,预测TTF-1、CK5/6及P63的表达,从而推测其生物学行为,阻止或延缓肿瘤进展。Objective The correlation between MSCT signs and TTF-1,CK5/6 and P63 expression was observed and studied,in order to speculate their biological behavior through CT examination early in the neoplastic lesions,and to improve the prognosis of patients with cystic cavity lung cancer.Methods Clinicopathological data and imaging findings of 35 patients with pathologically confirmed cystic cavity lung cancer were analyzed retrospectively,and statistical analysis was used to explore the correlation between MSCT signs and pathological subtypes,TTF-1,CK5/6,and P63 expression.Results The mean age of patients in the cystic cavity-type squamous carcinoma group(60.5±7.8)years was higher than in the invasive adenocarcinoma group(53.0±10.3)years and higher than in the in situ and microinvasive adenocarcinoma group(40.9±11.0)years.Ground glass signs appeared in situ and microinvasive adenocarcinoma(100%).The squamous carcinoma group had the highest proportion of cases(83.3%)and wall nodules(83.3%).The proportion of invasive adenocarcinoma groups showed more separated signs(81.8%)than in the other two groups.Vascular tract signature and ground glass signature of cystic cavity-type lung cancer were correlated with the positive expression of immunohistochemical TTF-1.The segmentation features of cystic lung cancer were correlated with positive expression of immunohistochemical CK5/6.The Mascalchi type I,leaf segmentation,and wall nodule signs of cystic cavity lung cancer were correlated with the positive expression of immunohistochemical P63.Conclusion Through patient age,Mascalchi classification,leaf segmentation,wall nodules,grinding glass,and vascular tract collection can predict the pathological subtype and positive expression of TTF-1,CK5/6 and P63,so as to speculate its biological behavior in the early stage of tumor lesions and improve the prognosis of patients with cystic lung cancer.

关 键 词：囊腔型肺癌 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]