肠道微生态在肝硬化及其并发症发生与治疗中的作用  

The role of intestinal microecology in the occurrence and treatment of liver cirrhosis and its complications

作　　者：夏巧云 鲁晓岚 XIA Qiaoyun;LU Xiaolan(Department of Gastroenterology,Pudong Medical Center Affiliated to Fudan University,Shanghai 201399,China)

机构地区：[1]复旦大学附属浦东医院消化内科,上海201399

出　　处：《西南医科大学学报》2023年第5期400-403,433,共5页Journal of Southwest Medical University

基　　金：国家自然科学基金(82070587);浦东新区消化临床特色学科项目(PWYts2021-11)。

摘　　要：肝硬化及其并发症严重威胁人类健康,明确其发病机制,寻找治疗相关疾病的有效方案迫在眉睫。目前越来越多的研究发现肠道微生态可以通过破坏肠道黏膜完整性、促进炎症因子的表达、引起肠道菌群易位等多种机制促进肝硬化及其并发症的发生及进展,靶向肠道微生态可能成为未来治疗肝硬化及其相关并发症的新方式。因此,本文就肠道菌群在肝硬化及其相关并发症发生及治疗中的作用和可能机制做一评述,明确目前基于肠道微生态在肝硬化及其相关并发症发生与治疗中的作用,为未来肝硬化发病机制及其相关并发症的治疗研究提供参考。Liver cirrhosis and its complications seriously threaten human health,so it is urgent to clarify its pathogenesis and find effective treatments for related diseases.Increasingly,studies have found that the intestinal microbiota can promote the occurrence and progression of cirrhosis and its complications through various mechanisms,such as disrupting the integrity of the intestinal mucosa,promoting the expression of inflammatory factors,and causing intestinal flora translocation.Therefore,targeted intestinal microecology may become a new way to treat cirrhosis and its complications in the future.This review analyzed the role and possible mechanisms of gut microbiota in the occurrence and treatment of liver cirrhosis by consulting relevant literature,and provides insights into the current status and future directions of research on the pathogenesis and treatment of liver cirrhosis.

关 键 词：肠道微生态 肝硬化 肝硬化并发症 

分 类 号：R575[医药卫生—消化系统]