基于PET/CT探讨汉族与维吾尔族2型糖尿病受检者肠道^(18)F-氟代脱氧葡萄糖摄取差异及影响因素  

Exploration of the differences of the^(18)F-FDG uptake in intestine between Han and Uighur nationalities subjects with T2DM and the influence factor of that based on PET/CT

作　　者：沈荣芳 梅丽努尔·阿布都热西提[2] 乃比江·阿布都西库 SHEN Rong-fang;MELINUR Abduresiti;NABIJAN Abdu-shiku(不详;State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia of Xinjiang Uyghur Autonomous Region,Kashgar 844000,China)

机构地区：[1]新疆维吾尔自治区中亚高发病成因与防治国家重点实验室,新疆喀什844000 [2]喀什地区第一人民医院核医学中心,新疆喀什844000

出　　处：《中国医学装备》2023年第9期65-70,共6页China Medical Equipment

基　　金：2021年度省部共建中亚高发病成因与防治国家重点实验室代谢病专项(SKL-HIDCA-2021-DX10)“喀什地区维吾尔族与汉族2型糖尿病患者结肠18F-FDG生理性摄取与肠道菌群基因相关因素的研究”。

摘　　要：目的:基于正电子发射断层扫描(PET)/CT,探讨汉族及维吾尔族2型糖尿病(T2DM)患者对^(18)F-氟代脱氧葡萄糖(^(18)F-FDG)生理性摄取差异及影响因素。方法:选取医院收治的180例T2DM患者,按照是否口服二甲双胍(MET)分为口服MET组和未口服MET组,每组90例(其中维吾尔族与汉族各45例);另选取同期进行体检的90名健康检查者为健康对照组(其中维吾尔族与汉族各45名)。所有受检者均行^(18)F-FDGPET/CT扫描,比较不同组别、不同民族受检者肠道对^(18)F-FDG的最大标准化摄取值(SUV_(max)),同时比较3组不同民族受检者一般临床资料及相关血液学指标与肠道SUV_(max)的相关性。结果:健康对照组、未口服MET组及口服MET组3组中的维吾尔族受检者SUV_(max)均明显高于汉族,差异有统计学意义(t=-2.89,t=-5.06,t=-4.84;P<0.05)。3组汉族及维吾尔族受检者的SUV_(max)比较有统计学意义(F=15.64,F=15.88;P<0.05)。口服MET组汉族及维吾尔族受检者SUV_(max)均明显高于健康对照组汉族及维吾尔族受检者(t=9.43,t=8.87;P<0.05);口服MET组的两族受检者的SUV_(max)均明显高于未口服MET组(t=8.99,t=9.38;P<0.05)。健康对照组中,汉族及维吾尔族受检者SUV_(max)与甘油三酯(TG)、低密度脂蛋白(LDL)及体脂率呈正相关性(r_(TG)=0.295,r=0.323;r_(LDL)=0.373,r=0.437;r_(体脂率)=0.475,r=0.544;P<0.05),与高密度脂蛋白(HDL)呈负相关性(r=-0.302,r=-0.38;P<0.05)。未口服MET组中,汉族及维吾尔族受检者^(18)F-FDG的摄取与空腹血糖(BG)及糖化血红蛋白(Hb A1c)均呈负相关性(r_(BG)=-0.284,r=-0.364;r_(HbA1c)=-0.336,r=-0.402;P<0.05)。BG≤8 mmol/L的汉族及维吾尔族的受检者SUV_(max)显著高于BG>8 mmol/L的受检者(t=6.71,t=6.44;P<0.05);HbA1c≤7.0%汉族及维吾尔族的受检者SUV_(max)高于HbA1c>7.0%的受检者(t=4.86,t=8.31;P<0.05)。结论:健康人群中,维吾尔族肠道SUV_(max)值较汉族明显增高。口服MET的T2DM患者血糖控制水平与^(18)F-FDG摄�Objective:To explore the differences of physiological uptake for fluoro-18-deoxyglucose(^(18)F-FDG)between Han and Uighur nationality subjects with type 2 diabetes mellitus(T2DM)and the influence factors of that based on positron-emission tomography/computed tomography(PET/CT).Methods:A total of 180 T2DM patients who admitted to hospital were selected,and they were divided into oral metformin(MET)group and non-oral MET group according to whether they took MET by mouth,with 90 cases in each group that included 45 Han nationality subjects and 45 Uighur nationality subjects in each group.At the same time,the other 90 health subjects who underwent physical examination were divided into health control group,which included 45 Han nationality subjects and 45 Uighur nationality subjects in health control group.All of subjects underwent^(18)F-FDG PET/CT scan,and the maximum standard uptake value(SUV_(max))of different groups and different nationalities for^(18)F-FDG were compared.At the same time,the generally clinical data between different nationalities in each group were compared,and the correlations of relevant blood indicators and the intestine SUV_(max)in different nationalities in each group were analyzed.Results:The SUV_(max)values of Uygur subjects were significantly higher than those of Han subjects in each group of healthy control group,non-oral MET group and oral MET group,with statistically significant differences(t=-2.89,t=-5.06,t=-4.84,P<0.05),respectively.There were significant differences in SUV_(max)value of same nationality among three groups(F=15.64,F=15.88,P<0.05),respectively.The SUV_(max)values of Han subjects and Uygur subjects in oral MET group were significantly higher than those in health control group(t=9.43,t=8.87,P<0.05),respectively.The SUV_(max)values of Han subjects and Uygur subjects in oral MET group were significantly higher than those in nonoral MET group(t=8.99,t=9.38,P<0.05),respectively.In health control group,the SUV_(max)values both of Han and Uygur subjects were positive correlat

关 键 词：二甲双胍(MET) 2型糖尿病(T2DM) 汉族 维吾尔族 ^(18)F-氟代脱氧葡萄糖(^(18)F-FDG) 

分 类 号：R574.62[医药卫生—消化系统]