外周血炎症指标SIRI和淋巴结转移状态在阴茎鳞状细胞癌手术患者中的预后价值  

Prognostic value of SIRI and lymph node metastasis in patients with penile squamous cell carcinoma undergoing surgery

作　　者：李玉[1] 孔令全 黄涛[1] LI Yu;KONG Lingquan;HUANG Tao(Department of Urological Oncology Surgery,The First Affiliated Hospital of USTC,Anhui Provincial Hospital,Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)泌尿肿瘤外科,合肥230001

出　　处：《现代泌尿生殖肿瘤杂志》2023年第4期212-217,共6页Journal of Contemporary Urologic and Reproductive Oncology

摘　　要：目的探讨炎症相关指标中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、淋巴细胞/单核细胞比值、系统免疫-炎症指数、系统炎症反应指数(SIRI)及临床相关因素与阴茎鳞状细胞癌(SCCP)患者手术预后的关系。方法回顾性分析2015年9月至2021年9月我院82例SCCP手术患者的临床及随访资料,采用Kaplan-Meier法绘制生存曲线、Cox回归模型进行单因素和多因素分析,预测影响SCCP患者术后预后的因素。结果根据受试者工作特征曲线计算得出术前SIRI最佳临界值为1.56,曲线下面积为0.783,敏感性为85.7%,特异性为74.7%。多因素Cox分析结果显示,淋巴结转移(N_(1~3),HR=6.71,95%CI:2.21~20.36;HR=6.98,95%CI:1.52~31.96)、高SIRI值(SIRI≥1.56,HR=15.49,95%CI:4.09~58.69;HR=20.52,95%CI:2.40~175.24)均是SCCP患者术后无进展生存期及总生存期的独立危险因素。结论SCCP患者术后多数预后良好,淋巴结转移、高SIRI值的患者预后不良。SIRI最佳临界值为1.56,SIRI可作为SCCP患者术后可靠的预后标志物。Objective To explore the relationship between inflammatory indicators neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),lymphocyte-to-monocyte ratio(LMR),systemic immune-inflammation response index(SII),systemic inflammation response index(SIRI),clinical related factors and surgical prognosis of patients with squamous cell carcinoma of the penis(SCCP).Methods The clinical and follow-up data of 82 patients undergoing SCCP surgery in our hospital from September 2015 to September 2021 were retrospectively analyzed.Kaplan-Meier method was used to draw survival curve and Cox regression model was used for univariate and multivariate analysis,so as to predict the factors affecting postoperative prognosis of patients with SCCP.Results According to ROC curve,the optimal critical value of preoperative SIRI was 1.56,the area under the ROC curve was 0.783,the sensitivity was 85.7%,and the specificity was 74.7%.Multivariate Cox analysis showed that lymph node metastasis(N_(1-3),HR=6.71,95%CI:2.21-20.36;HR=6.98,95%CI:1.52-31.96),high SIRI value(SIRI≥1.56,HR=15.49,95%CI:4.09-58.69;HR=20.52,95%CI:2.40-175.24)were independent risk factors for postoperative progression-free survival and overall survival in patients with SCCP.Conclusions Most patients with SCCP have a good prognosis after surgery,while those with lymph node metastasis and high SIRI value have a poor prognosis.The optimal critical value for SIRI is 1.56.SIRI can be used as a reliable prognostic marker for patients with SCCP after surgery.

关 键 词：癌 鳞状细胞 阴茎 预后 危险因素 

分 类 号：R737.27[医药卫生—肿瘤]