青少年鼻咽血管纤维瘤中HSP90表达及临床意义  

HSP90 expression and clinical characteristics in juvenile nasopharyngeal angiofibroma

作　　者：王娟[1] 王泽 王雪霖 唐焕文 WANG Juan;WANG Ze;WANG Xuelin;TANG Huanwen(Department of Facial Features,970 Hospital,Joint Service Support Force of the Chinese People′s Liberation Army,Yantai 264000,Shandong,China)

机构地区：[1]中国人民解放军联勤保障部队第970医院五官科,山东烟台264000

出　　处：《西部医学》2023年第9期1315-1319,共5页Medical Journal of West China

基　　金：烟台市科技创新发展计划项目(20190132)。

摘　　要：目的探讨青少年鼻咽血管纤维瘤(JNA)中热休克蛋白90(HSP90)的表达及其与肿瘤复发的关联。方法回顾性分析了2018年—2022年在我院接受手术治疗的组织学诊断为JNA的男性患者60例,使用包含60例JNA患者和10例对照受试者的组织微阵列进行免疫组织化学以评估HSP90表达,通过Pearson卡方、Spearman以及单变量和多变量Cox回归分析HSP90表达与临床病理特征和肿瘤复发的关系。结果与正常中鼻甲样本相比,免疫组织化学显示JNA中HSP90高表达。HSP90高表达与微血管密度(MVD)(R=0.379,P=0.001)、雌激素受体α(ER-α)(R=0.396,P=0.001)、血管内皮生长因子(VEGF)(R=0.612,P<0.001)和JNA复发(P=0.011)呈正相关,是复发时间的独立预后因素(HR=3.251,95%CI:1.187-8.634,P=0.012)。结论HSP90可能是接受手术治疗的JNA患者的独立预后标志物。Objective To evaluate heat shock protein 90(HSP90)expression in juvenile nasopharyngeal angiofibroma(JNA)and its association with tumor recurrence.Methods Immunohistochemistry was performed to assess HSP90 expression using tissue microarrays containing 60 JNA patients and 10 control subjects.The associations of HSP90 expression with clinicopathological features and tumor recurrence were analyzed through Pearson,Spearman,univariable and multivariable cox regression methods.Results Immunohistochemistry revealed high HSP90 expression in JNA compared with normal middle turbinate samples.High expression of HSP90,which correlated with MVD(R=0.379,P=0.001),ER-a(R=0.396,P=0.001),VEGF(R=0.612,P<0.001)and JNA recurrence(P=0.011),was an independent prognostic factor of time to recurrence(HR=3.251,95%CI:1.187-8.634,P=0.012).Conclusion HSP90 may be an independent prognostic marker in JNA patients administered surgical treatment.

关 键 词：青少年鼻咽血管纤维瘤 热休克蛋白90 免疫组化 组织微阵列 进展标志物 

分 类 号：R739.62[医药卫生—肿瘤]