老年高血压脑出血患者血清电解质、NLRP3、瘦素水平变化与疾病严重程度及预后的关系  

The changes of serum electrolytes,nucleotide-binding oligomerization domain-like receptor 3,and leptin levels in patients with hypertensive intracerebral hemorrhage and their relationship with disease severity and prognosis

作　　者：曹雅红 高鹤 李碧青 徐雪良 曹静 盛月峰 CAO Ya-hong;GAO He;LI Bi-qing;XU Xue-liang;CAO Jing;SHENG Yue-feng(Clinical Laboratory,Tongxiang Hospital of Traditional Chinese Medicine,Zhejiang 314500,China;不详)

机构地区：[1]桐乡市中医医院检验科,浙江314500 [2]桐乡市中医医院内二病区

出　　处：《中国卫生检验杂志》2023年第16期2003-2007,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨老年高血压脑出血(HICH)患者血清阴性电解质、核苷酸结合寡聚化结构域样受体3(NLRP3)、瘦素水平变化与患者疾病严重程度及预后的关系。方法本研究采用病例对照研究方案,选取桐乡市中医医院神经内科2018年8月—2022年6月收治的HICH患者103例(HICH组)、选取健康体检志愿者100例作为对照组,对比2组研究对象的血清氯离子、无机磷、阴离子间隙(AG)、NLRP3 mRNA、瘦素水平,并按照患者的病情严重程度、预后结局对HICH组进行分层对比,采用logistic回归因素模型分析各项指标与患者预后结局的关系。结果HICH组患者的血清氯离子、AG、NLRP3 mRNA、瘦素水平均高于对照组,HICH组患者的血清无机磷水平低于对照组(P<0.05);重度HICH组患者的血清氯离子、AG、NLRP3 mRNA、瘦素水平均高于轻中度HICH组患者,重度HICH组患者的血清无机磷水平低于轻中度组(P<0.05);预后良好患者的血清氯离子、AG、NLRP3 mRNA、瘦素水平均高于预后不良患者,预后良好患者的血清无机磷水平低于预后不良患者(P<0.05);logistic回归模型结果显示:合并冠心病、脑出血量≥30 ml、患者病情重度、血清AG高水平、NLRP3 mRNA高水平表达、瘦素高水平是HICH患者不良预后的独立危险因素(P<0.05)。结论HICH患者的血清氯离子、AG、NLRP3 mRNA、瘦素水平较非HICH人群显著增高、血清无机磷显著降低,且与患者病情严重程度有关,其中血清AG、NLRP3 mRNA、瘦素高水平与患者不良预后结局有关。Objective This paper aims to investigate the changes of serum negative electrolytes,nucleotide-binding oligomerization domain-like receptor 3(NLRP3)and leptin levels in elderly patients with hypertensive intracerebral hemorrhage(HICH)and their relationship with the severity of the disease and prognosis.Methods In this study,a case-control study was adopted.103 HICH patients(HICH group)admitted to the Department of Neurology of our Hospital from August 2018 to June 2022 were selected,and 100 cases for health examination were selected as the control group.Serum chloride ion,inorganic phosphorus,anion gap(AG),NLRP3 mRNA,and leptin levels were compared,and the HICH group was stratified and compared according to the severity of the patient’s disease and prognosis.Logistic regression factor model was used to analyze the relationship between each index and patient prognosis.Results The serum levels of chloride ion,AG,NLRP3 mRNA and leptin in the HICH group were higher than those in the control group,and the serum inorganic phosphorus levels in the HICH group were lower than those in the control group,and the differences in the above indicators were statistically significant(P<0.05).The serum levels of chloride,AG,NLRP3 mRNA and leptin in the severe HICH group were higher than those in the mild-moderate HICH group,and the serum inorganic phosphorus levels in the severe HICH group were lower than those in the mild-moderate group,and the differences between the two groups were statistically significant(P<0.05).The serum levels of chloride ion,AG,NLRP3 mRNA and leptin in patients with good prognosis were higher than those of patients with poor prognosis,and the serum inorganic phosphorus level of patients with good prognosis was lower than that of patients with poor prognosis(P<0.05).Logistic regression model results showed that combined coronary heart disease,cerebral hemorrhage volume≥30 ml,severe disease,high level of serum AG,high expression of NLRP3 mRNA,high level of leptin were independent risk factors for poor p

关 键 词：老年 高血压脑出血 阴性电解质 核苷酸结合寡聚化结构域样受体3 瘦素 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]