艾塞那肽联合多烯磷脂酰胆碱治疗酒精性脂肪肝及对血清HMGB1、脂联素水平的影响  

Efficacy of exenatide combined with polyene phosphatidylcholine in the treatment of alcoholic fatty liver and its effect on serum HMGB1 and APN levels

作　　者：章秀丽 李庆群 张绍荣 张楚新 ZHANG Xiuli;LI Qingqun;ZHANG Shaorong;ZHANG Chuxin(Department of Gastroenterology,Shenzhen Hospital of University of Chinese Academy of Sciences(Guangming),Shenzhen 518107,Guangdong,China)

机构地区：[1]中国科学院大学深圳医院消化内科,广东深圳518107

出　　处：《广州医科大学学报》2023年第2期44-47,共4页Academic Journal of Guangzhou Medical University

摘　　要：目的:探究艾塞那肽联合多烯磷脂酰胆碱治疗酒精性脂肪肝的效果及对血清HMGB1、脂联素(APN)水平的影响。方法:回顾性选取2019年2月至2021年2月在我院治疗的酒精性脂肪肝患者126例为此次试验的对象,根据患者的治疗手段差异分为2组,对照组62例患者给予艾塞那肽联治疗;试验组64例患者在对照组的基础上给予多烯磷脂酰胆碱。比较两组患者治疗效果;比较两组患者治疗前后4周血清HMGB1、APN、血脂[甘油三酯(TG)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL⁃C)]水平。结果:相对于对照组总有效率83.87%(52/62),试验组总有效率96.87%(62/64)更高(P<0.05);相对于对照组,试验组HMGB1、TG、TC、LDL⁃C更低,APN、HDL⁃C更高(P<0.05);在治疗4周期间,两组患者均未出现明显不良反应(P<0.05)。结论:艾塞那肽联合多烯磷脂酰胆碱应用于酒精性脂肪肝患者,临床效果较好,可以改善患者的血脂,降低HMGB1,提高APN,并且不会增加不良反应。Objective:To explore the clinical efficacy of exenatide combined with polyene phosphatidylcholine in the treatment of alcoholic fatty liver,and to analyze its effect on serum high⁃mobility group box 1 protein(HMGB1)and adiponectin(APN)levels.Methods:One hundred and twenty⁃six patients with alcoholic fatty liver in our hospital from February 2019 to February 2021 were retrospectively enrolled and classified into two groups according to different treatment regimens.Control group(n=62)received exenatide therapy,based on this,experimental group(n=64)received polyene phosphatidylcholine.Then comparison was conducted on the clinical efficacy rate,serum levels of HMGB1,APN and blood lipid parameters[triglyceride(TG),total cholesterol(TC),high density lipoprotein⁃cholesterol(HDL⁃C),low density lipoprotein⁃cholesterol(LDL⁃C)]and adverse reactions during treatment.Results:The overall efficacy rate was 96.87%(62/64)in experimental group,which was higher than 83.87%(52/62)in control group(P<0.05).In contrast to the control group,experimental group had lower APN,TG,TC and LDL⁃C levels as well as higher HDL⁃C levels(P<0.05).No significant adverse effects were observed in either group during the 4⁃week treatment period(P<0.05).Conclusions:Application of exenatide combined with polyene phosphatidylcholine is effective in patients with alcoholic fatty liver,which can ameliorate the blood lipids,reduce HMGB1 and increase APN in patients with no additional adverse reactions.

关 键 词：艾塞那肽 多烯磷脂酰胆碱 酒精性脂肪肝 HMGB1 APN 

分 类 号：R575.5[医药卫生—消化系统]