The moderating role of NTSR1 polymorphisms on personality and coping styles among breast cancer patients  

作　　者：Ran Hao Jin-Fan Zuo Meng Zhang Hao-Yu Jin Jie Hu Yi-Xin Qi 

机构地区：[1]School of Nursing,Hebei Medical University,Shijiazhuang 050000,China [2]Department of Critical Medicine,The Affiliated Hospital of Qingdao University,Qingdao 266000,China [3]School of Public Health,Hebei Medical University,Shijiazhuang 050000,China [4]Department of Breast Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050000,China

出　　处：《Psychosomatic Medicine Research》2023年第3期7-15,共9页心身医学研究

基　　金：This work was supported by the National Natural Science Foundation of China[grant number 72074067];S&T Program of Hebei[grant number 21377729D];Natural Science Foundation of Hebei Province[grant numbers H2020206483,H2021206289];Technical Innovative Youth Talents of Hebei Medical University[grant number TJSK202103];Young scientific and technological talents support program of Hebei Medical University[grant number CYCZ2021012].

摘　　要：Background:Some personality traits could be a predictor for coping styles.The objective of this investigation was to examine the correlation between personality traits and coping mechanisms in the context of gene regulation among breast cancer patients.Material and methods:This cross-sectional study was performed in 2021.A total of 200 breast cancer patients were included in this study.Data were collected using the Trait Coping Style Questionnaire(TCSQ)and the Eysenck Personality Questionnaire-Revised Short Scale for Chinese(EPQ-RSC).And individuals’blood was tested for genotype.Results:The findings indicated that there existed an inverse relationship between extraversion and negative coping style while also demonstrating a significant association between extraversion and positive coping style.Neuroticism was positively correlated with negative coping style but negatively with positive coping style.The SNP of NTSR1 only moderated the relationship between neuroticism and negative coping styles in breast cancer patients.Conclusion:The present investigation delves into the correlation between personality traits and coping mechanisms at the molecular level in breast cancer patients.

关 键 词：PERSONALITY coping style single nucleotide polymorphism breast cancer 

分 类 号：R73[医药卫生—肿瘤]