短链脂肪酸及其受体在结肠癌中的作用  

Role of short-chain fatty acids and its receptors in colon cancer

作　　者：孔玲玲[1] 石磊[1] 张冬[1] 贺延新[1] 田字彬[2] KONG Lingling;SHI Lei;ZHANG Dong;HE Yanxin;TIAN Zibin(Department of Gastroenterology,the Affiliated Qingdao Central Hospital of Qingdao University,Qingdao 266042;Department of Gastroenterology,the Affiliated Hospital of Qingdao University,China)

机构地区：[1]青岛大学附属青岛市中心医院消化内科,山东青岛266042 [2]青岛大学附属医院消化内科

出　　处：《胃肠病学和肝病学杂志》2023年第9期1058-1060,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：食物中的营养物质及其代谢产物参与结肠癌的发生发展。食物中的脂肪、碳水化合物、蛋白、膳食纤维以及益生菌均影响肠道菌群,与胃肠道的健康和疾病密不可分,特别在结肠,脂肪及膳食纤维的代谢产物参与调节肠道炎症等作用。GPR43、GPR41、GPR109A均为短链脂肪酸受体,虽然既往已经报道短链脂肪酸及其受体在抑制结肠肿瘤中的相关机制,但本文通过总结近年来新的相关研究,为短链脂肪酸及其受体抑制结肠癌新的机制作一综述。Nutrients and metabolites are involved in development of colon cancer.Fat,carbohydrate,protein,dietary fiber and probiotics which all affect intestinal flora in the gut and are closely related to the health and diseases of the gastrointestinal tract.Especially in the colon,the metabolites of fat and dietary fiber are involved in regulating intestinal inflammation.GPR43,GPR41 and GPR109A are short-chain fatty acid receptors.Although the mechanisms of short-chain fatty acids and their receptors in the inhibition of colon cancer have been reported in the past,this paper reviewed the new mechanisms of short chain fatty acids and their receptors in the inhibition of colon cancer by summarizing the new studies in recent years.

关 键 词：短链脂肪酸 受体 结肠癌 

分 类 号：R735.3[医药卫生—肿瘤]