探讨T2DM人群中25(OH)D与代谢相关性脂肪肝的相关性  

Correlation between 25(OH)D and metabolically related fatty liver in T2DM population

作　　者：马言 田高鹏 石兴文 孙婷 谢晶晶 甄东户[1,2] MA Yan;TIAN Gaopeng;SHI Xingwen;SUN Ting;XIE Jingjing;ZHEN Donghu(The First Clinical College of Lanzhou University,Lanzhou 730000,Gansu,China;Department of Endocrinology,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院内分泌科,兰州730000

出　　处：《中国临床药理学与治疗学》2023年第9期1018-1026,共9页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：上海市医药卫生发展基金会糖尿病临床研究项目(I期10研究);甘肃省自然科学基金(21JR1RA096);国家标准化代谢性疾病管理中心专项研究基金(2018-mmczxjj-3);医学院校硕士研究生学位论文质量提升策略研究(lzuyxcx-2022-112;820809036)。

摘　　要：目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)人群中25-羟维生素D[25 hydroxyvitamin D,25(OH)D]与代谢相关性脂肪性肝病(metabolic-associated fatty liver disease,MAFLD)的相关性。方法:从兰州大学第一医院国家标准化代谢性疾病管理中心(National Center for Standardized Metabolic Disease Control,MMC)招募2406名符合研究标准的受试者。按25(OH)D四分位分组将人群分为Q1、Q2、Q3、Q4,比较四组间代谢相关性脂肪性肝病(metabolic-associated fatty liver disease,MAFLD)的患病情况和相关临床指标,采用Logistic回归分析MAFLD的影响因素,使用限制性立方样条(restricted cubic spline,RCS)探索25(OH)D与MAFLD之间的关系。结果:不同维生素D水平MAFLD患病率存在差异,25(OH)D水平高的人群MAFLD患病率低;合并MAFLD的人25(OH)D水平低于单纯T2DM者,维生素D缺乏的人数也相对较多;多因素回归分析提示25(OH)D与MAFLD患病风险无关;RCS分析也提示25(OH)D与MAFLD的患病风险无关。结论:MAFLD在维生素D水平低的人群中患病率高,多因素调整后维生素D与MAFLD的患病风险无关。AIM:To investigate the correlation between 25-hydroxyvitamin D and metabolically associated fatty liver disease in type 2 diabetes mellitus.METHODS:A total of 2406 subjects in Standardized Metabolic Disease Control were recruited from the National Center for Standardized Metabolic Disease Control in The First Hospital of Lanzhou University.The population was divided into Q1,Q2,Q3 and Q4 according to 25(OH)D quartile.The prevalence of MAFLD and related clinical indicators among the four groups were compared,and the influencing factors of MAFLD were analyzed by Logistic regression.Restricted cubic spline(RCS)was used to explore the relationship between 25(OH)D and MAFLD.RESULTS:The prevalence of MAFLD was different with different vitamin D levels.The prevalence of MAFLD was lower in the group with high 25(OH)D level.The level of 25(OH)D in patients with MAFLD was lower than that in patients with T2DM alone,and the number of vitamin D deficiency was relatively higher.Multivariate regression analysis showed that 25(OH)D was not associated with the risk of MAFLD.RCS analysis also suggested that 25(OH)D was not associated with the risk of MAFLD.CONCLUSION:The prevalence of MAFLD is high in people with low vitamin D level,and vitamin D is not associated with the risk of MAFLD after multivariate adjustment.

关 键 词：25(OH)D 代谢相关性脂肪性肝病 2型糖尿病 

分 类 号：R575.5[医药卫生—消化系统] R589.2[医药卫生—内科学]