阿替普酶急诊静脉溶栓对超早期急性脑梗死患者的疗效及安全性  

The Efficacy and Safety of emergency intravenous Thrombolysis with Alteplase in Patients with super-early acute cerebral Infarction

作　　者：田城坡 TIAM Chengpo(Department of Emergency,Xuchang Traditional Chinese Medicine Hospital,Xuchang Henan 461000,China)

机构地区：[1]河南许昌中医院急诊科,河南许昌461000

出　　处：《临床研究》2023年第10期44-46,共3页Clinical Research

摘　　要：目的探讨超早期急性脑梗死(ACI)患者采用阿替普酶(rt-PA)急诊静脉溶栓的疗效及安全性。方法选取2021年11月至2022年12月在河南许昌中医院急诊科接受治疗的超早期ACI患者共计116例,根据随机数字表法分为研究组(n=58)与对照组(n=58),对照组采用尿激酶急诊静脉溶栓治疗,研究组采用rt-PA急诊静脉溶栓治疗,对两组临床疗效、神经功能、凝血功能及不良反应进行比较。结果研究组治疗有效率(98.28%)较对照组(84.48%)更高,差异有统计学意义(P<0.05);两组治疗后美国国立卫生研究院卒中量表(NIHSS)评分降低,研究组较对照组更低,差异有统计学意义(P<0.05);两组治疗后凝血酶时间(TT)、凝血酶原时间(PT)延长,差异有统计学意义(P<0.05),纤维蛋白原(FIB)提高,差异有统计学意义(P<0.05),研究组TT、PT较对照组更长,FIB更高,差异有统计学意义(P<0.05);研究组不良反应发生率(3.45%)较对照组(17.24%)更低,差异有统计学意义(P<0.05)。结论rt-PA急诊静脉溶栓应用于超早期ACI患者治疗中,可提高临床疗效,改善神经功能及凝血功能,减少不良反应。Objective To investigate the efficacy and safety of emergency intravenous thrombolysis with alteplase(rt-PA)in patients with super-early acute cerebral infarction(ACI).Methods A total of 116 patients with super-early ACI who received treatment in the emergency department of Xuchang Traditional Chinese Medicine Hospital from November 2021 to December 2022 were selected and randomly divided into a study group(n=58)and a control group(n=58)based on a random number table.The control group received emergency intravenous thrombolysis with urokinase,while the study group received emergency intravenous thrombolysis with rt-PA.The clinical efficacy,neurological function,coagulation function,and adverse reactions of the two groups were compared.Results The treatment effective rate(98.28%)of the study group was higher than that of the control group(84.48%),and the difference was statistically significant(P<0.05);After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores of the two groups decreased,and the study group had a lower score compared to the control group,with a statistically significant difference(P<0.05);After treatment,the thrombin time(TT)and prothrombin time(PT)of the two groups were prolonged,with a statistically significant difference(P<0.05).Fibrinogen(FIB)was increased,with a statistically significant difference(P<0.05).The TT and PT of the study group were longer than those of the control group,and FIB was higher,with a statistically significant difference(P<0.05);The incidence of adverse reactions in the study group(3.45%)was lower than that in the control group(17.24%),and the difference was statistically significant(P<0.05).Conclusion The application of rt-PA emergency intravenous thrombolysis in the treatment of super-early ACI patients can improve clinical efficacy,improve neurological and coagulation functions,and reduce adverse reactions.

关 键 词：阿替普酶 急诊静脉溶栓 超早期急性脑梗死 疗效 安全性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]