精神分裂症患者TC/HDL ApoA1 Lp(a)水平变化及与代谢综合征的关系分析  

Changes in TC/HDL,ApoA1 and Lp(a)Levels in Patients with Schizophrenia and Their Relationship with Metabolic Syndrome

作　　者：鲁文 龚陈 向文 赵云飞 李承美[1] LU Wen;GONG Chen;XIANG Wen(Tianmen First People's Hospital,Hubei Tianmen 431700,China)

机构地区：[1]湖北省天门市第一人民医院精神科,湖北天门431700

出　　处：《河北医学》2023年第9期1564-1568,共5页Hebei Medicine

基　　金：湖北省卫生健康委员会科研项目,(编号:WJ2019T17)。

摘　　要：目的:探究精神分裂症患者总胆固醇/高密度脂蛋白(TC/HDL)、载脂蛋白A1(ApoA1)、脂蛋白(a)[Lp(a)]水平变化及与代谢综合征(MS)的关系。方法:遴选我院93例精神分裂症患者为研究对象,统计患者临床资料,采用CHOD-PAP、直接法及免疫比浊法检测患者血清TC/HDL、ApoA1、Lp(a)水平,根据是否并发MS将患者分为MS组(n=32)和非MS组(61),比较两组一般资料及血清TC/HDL、ApoA1、Lp(a)水平,采用多因素Logistic回归分析影响精神分裂症患者伴发MS的危险因素。结果:MS组BMI、SBP、DBP、FPG、血清TG、LDL-C水平均显著高于非MS组(P<0.05),HDL-C水平显著低于非MS组(P<0.05),两组性别、年龄、病程、吸烟史、饮酒史、抗精神药物使用、血清TC水平、PANSS评分比较差异无统计学意义(P>0.05);MS组TC/HDL、Lp(a)显著高于非MS组(P<0.05),ApoA1显著低于非MS组(P<0.05);多因素Logistic回归分析显示,BMI、FPG、血清TG、LDL-C、Lp(a)及TC/HDL是影响精神分裂症患者并发MS的危险因素,血清ApoA1为保护因素(P<0.05)。结论:血清TC/HDL、ApoA1、Lp(a)水平变化是精神分裂症患者并发MS影响因素,且TC/HDL、Lp(a)水平升高、ApoA1水平降低可加大患者MS发病风险。Objective:To explore the changes in total cholesterol/high density lipoprotein(TC/HDL),apolipoprotein A1(ApoA1)and lipoprotein(a)[Lp(a)]and their relationship with metabolic syndrome(MS)in patients with schizophrenia.Methods:A total of 93 patients with schizophrenia in the hospital were selected as the study subjects.General data of patients were counted.The levels of serum TC/HDL,ApoA1 and Lp(a)were detected by enzyme-linked immunosorbent assay,and the patients were divided into MS group(n=32)and non-MS group(n=61)according to whether they were complicated with MS.The general data and levels of serum TC/HDL,ApoA1 and Lp(a)were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the risk factors of MS in patients with schizophrenia.Results:The BMI,SBP,DBP,FPG,serum TG and LDL-C in MS group were significantly higher than those in non-MS group(P<0.05)while the level of HDL-C was significantly lower than that in non-MS group(P<0.05).There were no statistically significant differences in gender,age,course of disease,smoking history,drinking history,antipsychotic drug use,serum TC level,and PANSS score between the two groups(P>0.05).TC/HDL and Lp(a)in MS group were significantly higher than those in non-MS group(P<0.05)while ApoA1 was significantly lower than that in non-MS group(P<0.05).Multivariate Logistic regression analysis showed that BMI,FPG,serum TG,LDL-C,Lp(a)and TC/HDL were risk factors affecting MS in patients with schizophrenia,and serum ApoA1 was a protective factor(P<0.05).Conclusion:Serum TC/HDL,ApoA1 and Lp(a)levels are the influencing factors of MS in patients with schizophrenia,and the increases of TC/HDL and Lp(a)and the decrease of ApoA1 can increase the risk of MS in patients.

关 键 词：精神分裂症 代谢综合征 总胆固醇/高密度脂蛋白 载脂蛋白A1 脂蛋白(a) 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R589[医药卫生—临床医学]