免疫炎症因子在肝内胆管癌中的预测价值  

Value of immune-inflammatory factors in predicting intrahepatic cholangiocarcinoma

作　　者：刘桂玲[1] 窦杰 孟慧娟[2] 马炳奇[1] LIU Guiling;DOU Jie;MENG Huijuan;MA Bingqi(Department of Hepatopancreatobiliary Surgery,Affiliated Hospital of Weifang Medical University,Weifang,Shandong 261031,China;Department of Dermatology,Affiliated Hospital of Weifang Medical University,Weifang,Shandong 261031,China)

机构地区：[1]潍坊医学院附属医院肝胆胰外科,山东潍坊261031 [2]潍坊医学院附属医院皮肤科,山东潍坊261031

出　　处：《临床肝胆病杂志》2023年第9期2231-2236,共6页Journal of Clinical Hepatology

基　　金：潍坊市科学技术发展计划(医学类)(2022YX026);潍坊医学院附属医院科研创新计划项目(2022BSQD07);山东省医药卫生科技发展计划项目(202004011537)。

摘　　要：肝内胆管癌(ICC)是最常见的原发性肝脏恶性肿瘤之一,在过去20年中发病率持续上升。手术切除是ICC的主要治疗方式,但超半数患者在初诊时已失去手术机会,只能选择局部区域治疗或系统治疗。目前ICC的治疗效果并不理想。在ICC和其他实体肿瘤中,已发现一些炎症指标可能有效反映肿瘤内部的炎症状态,这些免疫炎症因子(IIF)与肿瘤进展及预后指标存在着明显的相关性,其均是基于血常规、C反应蛋白、白蛋白和肿瘤标志物等血液学指标计算得出,并可以分为三大类:直接炎症因子、肿瘤标志物和联合炎症因子。经过对比分析发现,联合炎症因子在ICC患者预后中的预测价值优于直接炎症因子和肿瘤标志物。推荐使用IIF中的炎症和肿瘤指标预后评分、全身炎症评分或全身炎症反应指数作为ICC患者生存预后的评分系统。Intrahepatic cholangiocarcinoma(ICC)is one of the most common primary liver malignancies,with an increasing incidence rate in the past two decades.Surgical resection is the main treatment method for ICC,but more than half of the patients have lost the opportunity for surgery at the time of initial diagnosis,with the only choice of locoregional or systemic treatment.At present,there is still a lack of satisfactory treatment outcomes for ICC.In ICC and other solid tumors,it has been found that some immune-inflammatory factors(IIFs)can effectively reflect the inflammatory state within the tumor,and these IIFs are significantly associated with tumor progression and prognostic markers.These IIFs are all calculated based on hematological parameters such as routine blood test results,C-reactive protein,albumin,and tumor markers,and they can be classified into three categories,i.e.,direct inflammatory factors,tumor markers,and combined inflammatory factors.Comparative analysis has shown that combined inflammatory factors has a better value than direct inflammatory factors and tumor markers in predicting the prognosis of ICC patients.It is recommended to use prognostic inflammatory and tumor score,systemic inflammation score,and systemic inflammation response index as the scoring systems for evaluating the survival and prognosis of ICC patients.

关 键 词：胆管上皮癌 生物标记 肿瘤 预后 

分 类 号：R735.8[医药卫生—肿瘤]