三种波前像差仪测量成年近视患者角膜高阶像差的一致性  

Agreement of corneal high-order aberrations measured by three wavefront aberrometers in myopic adults

作　　者：邹华鲜 陈琦[2] 李丽丽[2] 韦蝶凤[2] 毛合娟[2] 黄燕燕 陆鹏飞[2] 钟海彬[3] Hua-Xian Zou;Qi Chen;Li-Li Li;Die-Feng Wei;He-Juan Mao;Yan-Yan Huang;Peng-Fei Lu;Hai-Bin Zhong(Guilin Medical University,Guilin 541199,Guangxi Zhuang Autonomous Region,China;Department of Optometry,the People s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi Zhuang Autonomous Region,China;Department of Ophthalmology,the People s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]桂林医学院,中国广西壮族自治区桂林市541199 [2]广西壮族自治区人民医院视光科,中国广西壮族自治区南宁市530021 [3]广西壮族自治区人民医院眼科,中国广西壮族自治区南宁市530021

出　　处：《国际眼科杂志》2023年第10期1723-1731,共9页International Eye Science

基　　金：广西科技计划项目(No.桂科AD19245193)。

摘　　要：目的:评估Topcon KR-1W、i.Profiler、OPD-ScanⅢ三种波前像差仪测量成年近视患者角膜高阶像差的一致性。方法:前瞻性临床研究。收集2022-06/08在广西壮族自治区人民医院视光中心就诊的成年近视患者92例92眼,分别采用Topcon KR-1W、i.Profiler、OPD-ScanⅢ测量4、6mm瞳孔直径下角膜三、四阶像差,评估三种波前像差仪的差异性和一致性。结果:三种像差仪6mm瞳孔直径下测量值均高于4mm瞳孔直径下测量值。4mm瞳孔直径下三种像差仪Z_(4)^(-4)、Z_(4)^(-2)测量值均无差异(P>0.05),其余测量值均有差异(P<0.05);6mm瞳孔直径下三种像差仪测量值均有差异(P<0.05)。4mm瞳孔直径下三阶像差测量值、6mm瞳孔直径下三、四阶像差(除Z_(4)^(-2))测量值的95%LoA>0.1μm,一致性相关系数P c<0.90,显示一致性较差。三种像差仪4、6mm瞳孔直径下角膜高阶像差测量值相关性差异较大(r 4mm=0.215~0.805,P 4mm<0.05;r 6mm=0.561~0.916,P 6mm<0.001)。结论:Topcon KR-1W、i.Profiler与OPD-ScanⅢ测量4、6mm瞳孔直径下角膜三、四阶像差时测量结果存在差异性,一致性较差,临床应用中三种像差仪不可相互替代。AIM:To evaluate the agreement of corneal high-order aberrations from Topcon KR-1W,i.Profiler and OPD-ScanⅢwavefront aberrometers in myopic adults.METHODS:A prospective clinical study.A total of 92 adult patients(92 eyes)with myopia in the department of optometry,the People’s Hospital of Guangxi Zhuang Autonomous Region from June to August 2022 were enrolled.The third-order and fourth-order corneal aberrations at the pupil diameter of 4 and 6mm were measured by Topcon KR-1W,i.Profiler,and OPD-ScanⅢ,respectively.The difference and agreement of the three aberrometers were evaluated.RESULTS:The measurements at 6mm pupil diameter were all greater than those at 4mm pupil diameter.Although there were no statistical differences in the measurements of Z-44、Z-24 by the three aberrometers at 4 pupil diameter(P>0.05),there were statistical differences in other measurements(P<0.05).The aberration results measured by the three aberrometers were statistically different at the 6mm pupil diameter(P<0.05).The 95%limit of agreement(95%LoA)of the measurements of higher-order aberration,including the third-order aberrations at 4mm pupil diameter and the third-order and fourth-order aberrations at 6mm pupil diameter(except for the Z-24)were greater than 0.1μm.The concordance correlation coefficient(P c)was lower than 0.90,indicating a poor consistency.The correlation coefficients of corneal higher-order aberrations were significantly different among the three aberrometers at 4 and 6mm pupil diameter(r 4mm=0.215~0.805,P 4mm<0.05;r 6mm=0.561~0.916,P 6mm<0.001).CONCLUSION:There were significant differences in the measurements of the third-and fourth-order corneal aberrations at 4 and 6mm pupil diameter among Topcon KR-1W,i.Profiler,and OPD-ScanⅢ,and the agreements were poor,so they are not interchangeably in clinical applications.

关 键 词：Topcon KR-1W i.Profiler OPD-ScanⅢ 角膜像差 一致性 

分 类 号：R778.11[医药卫生—眼科]