VIM在子宫内膜癌组织中的表达及其与预后的关系  

Expression of VIM in endometrial carcinoma and its relationship with prognosis

作　　者：孟凡菲[1] 张亚军[2] 李明[1] 花茂方[1] 李建伟[1] 周哲[1] MENG Fanfei;ZHANG Yajun;LI Ming;HUA Maofang;LI Jianwei;ZHOU Zhe(Department of Gynecology,Lianyungang Maternal and Child Health Hospital,Lianyungang Jiangsu 222000,China;Department of Pathology,Lianyungang Maternal and Child Health Hospital,Lianyungang Jiangsu 222000,China)

机构地区：[1]江苏省连云港市妇幼保健院妇科,连云港222000 [2]江苏省连云港市妇幼保健院病理科,连云港222000

出　　处：《中国妇产科临床杂志》2023年第5期464-466,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：连云港市卫生科技项目(ZD202005)。

摘　　要：目的观察子宫内膜癌组织中波形蛋白(VIM)表达及其与预后的关系。方法选取2015年1月至2020年5月连云港市妇幼保健院收治的85例接受根治性子宫切除术治疗的子宫内膜癌患者,观察子宫内膜癌组织中VIM表达情况;全部患者均随访2年,根据预后分为预后不良组、良好组,分析VIM表达与子宫内膜癌患者预后的关系。结果子宫内膜癌患者组织中VIM阳性46例(54.12%);Ⅱ型、有淋巴结转移子宫内膜癌患者组织中VIM阳性占比高于Ⅰ型、无淋巴结转移患者,低分化、Ⅲ期子宫内膜癌组织中VIM阳性占比最高,其次为中分化、Ⅱ期,高分化、Ⅰ期最低(P<0.05);85例子宫内膜癌患者术后2年内预后不良率为22.35%;预后不良组子宫内膜癌组织中VIM阳性占比高于预后良好组(P<0.05);经Logistic回归分析结果显示,VIM阳性是子宫内膜癌术后预后不良的危险因素(OR>1,P<0.05)。结论不同临床病理特征的子宫内膜癌患者VIM表达存在差异,且VIM表达与子宫内膜癌患者临床预后有关。Objective To investigate the expression of vimentin(VIM)in endometrial carcinoma and its relationship with prognosis.Methods A prospective cohort study was conducted to observe the expression of VIM in endometrial cancer tissues from 85 patients undergoing radical hysterectomy in our hospital from January 2015 to May 2020.All patients were followed up for 2 years,and were divided into poor prognosis group and good prognosis group according to their prognosis.The relationship between the expression of VIM and the prognosis of endometrial cancer patients were analyzed.Results There were 46 cases(54.12%)with positive VIM in endometrial carcinoma tissues.The positive rate of VIM in patients with endometrial carcinoma of type Ⅱ and with lymph node metastasis was higher than that in patients with type Ⅰ and without lymph node metastasis.The positive rate of VIM in poorly differentiated and stage Ⅲ endometrial carcinoma was the highest,followed by moderately differentiated and stage Ⅱ,and the lowest in highly differentiated and stage Ⅰ(P<0.05).The poor prognosis rate of 85 patients with endometrial cancer within 2 years after surgery was 22.35%.The positive rate of VIM in endometrial cancer tissue of poor prognosis group was higher than that of good prognosis group(P<0.05).The results of logistic regression analysis showed that positive VIM was a risk factor for poor prognosis of endometrial cancer after surgery(OR>1,P<0.05).Conclusion The expression of VIM in endometrial cancer patients with different clinicopathological featureshere are different,and is related to the clinical prognosis.

关 键 词：子宫内膜癌 波形蛋白 临床病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]