苦黄颗粒联合水飞蓟宾胶囊治疗湿热蕴结型代谢相关脂肪性肝病的临床效果观察  

Clinical observation of Kuhuang granule combined with silybin capsule in treating metabolic associated fatty liver disease of dampness heat accumulation type

作　　者：孙伯洋 杨红梅[1] 梅建民 SUN Bo-yang;YANG Hong-mei;MEI Jian-min(Department of hepatobiliary surgery,seventh Medical Center,PLA General Hospital,(Beijing 100700),China.)

机构地区：[1]解放军总医院第七医学中心肝胆外科,北京100700

出　　处：《中西医结合肝病杂志》2023年第9期769-772,778,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：首都卫生发展科研专项(No.2018-2-2125);。

摘　　要：目的:观察苦黄颗粒联合水飞蓟宾胶囊治疗湿热蕴结型代谢相关脂肪性肝病(MAFLD)的临床疗效。方法:选取96例湿热蕴结型MAFLD患者,按随机数字表法将患者分成观察组和对照组,每组48例。对照组患者口服水飞蓟宾胶囊,观察组患者在对照组治疗基础上加用苦黄颗粒,疗程均为3个月。观察两组患者治疗前后谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)、直接胆红素(DBil)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)以及体质量指数(BMI)的变化,比较两组患者的临床疗效。结果:治疗后,观察组总有效率高于对照组(P<0.05);两组患者ALT、AST、TBil及DBil较治疗前均降低(P<0.05),观察组患者治疗后上述肝功能指标均明显低于对照组(P<0.05);两组患者LDL-C、TG及TC水平较治疗前均降低(P<0.05),HDL-C水平较治疗前均升高(P<0.05),且观察组治疗后LDL-C和TC水平较对照组低(P<0.05);治疗后,观察组患者肝脏彩超恢复正常率显著高于对照组(P<0.05);两组患者BMI、HbA1C和FBG较治疗前均显著降低(P<0.05),但观察组与对照组在BMI、HbA1c及FBG上比较无显著差异(P>0.05)。两组均未出现严重不良反应。结论:苦黄颗粒联合水飞蓟宾胶囊治疗湿热内蕴型MAFLD疗效显著,值得临床推广。Objective:To explore the clinical effect of Kuhuang granule combined with silybin capsule in the treatment of metabolic associated fatty liver disease(MAFLD)of dampness heat accumulation type.Methods:A total of 96 patients with dampness heat accumulation type MAFLD were selected and divided into an observation group and a control group according to the random number table method,all 48 cases.The control group took silibin capsules orally,and the observation group added Kuhuang granules on the basis of the control group.The course of treatment was three months.The clinical effects of the two groups were compared,and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil),direct bilirubin(DBil),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),fasting blood glucose(FBG),glycated hemoglobin(HbA1C)levels,and body mass index(BMI)were compared before and after treatment.Results:After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05);The indexes of ALT,AST,TBil and DBil in the two groups were all lower than those before treatment(P<0.05),and the above-mentioned liver function indexes in the observation group were significantly lower than those in the control group(P<0.05);The levels of LDL-C,TG and TC in the two groups were lower than those before treatment(P<0.05),and the levels of HDL-C were higher than those before treatment(P<0.05),and after treatment,the levels of LDL-C and TC in the observation group were lower than those in the control group(P<0.05);After treatment,the recovery rate of liver color Doppler ultrasound in the observation group was significantly higher than that in the control group(P<0.05);BMI,HbA1c and FBG in the two groups were significantly lower than those before treatment(P<0.05),but there was no significant difference in BMI,HbA1c and FBG between the observation group and the control group(P>0.05).No serious adverse reactions were found in bo

关 键 词：苦黄颗粒 代谢相关脂肪性肝病 湿热蕴结证 

分 类 号：R575.1[医药卫生—消化系统]