CircPVT1在肿瘤中的调控作用研究进展  

Research Progress on Regulatory Role of CircPVT1 in Tumors

作　　者：鲍浩霖 黄子越 李杰瀚 梁子鑫 余良 林宁 倪春节[4] 崔云甫[1] 徐艺[1,2,3,4,5] BAO Haolin;HUANG Ziyue;LI Jiehan;LIANG Zixin;YU Liang;LIN Ning;NIChunjie;CUI Yunfu;XU Yi(Department of Hepatopancreatobiliary Surgery,Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;Department of Pathology,School of Clinical Medicine,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China;Key Laboratory of Functional and Clinical Translational Medicine,Fujian Province University,Xiamen Medical College,Xiamen 361000,China;Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials,Yancheng Teachers University,Yancheng 224007,China;Key Laboratory of Myocardial Ischemia,Ministry of Education,Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院胆胰外科,哈尔滨150086 [2]香港大学李嘉诚医学院临床医学院病理学系,中国香港999077 [3]厦门医学院机能与临床转化福建省高校重点实验室,厦门361000 [4]盐城师范学院江苏省肿瘤靶向纳米诊疗材料工程研究中心,盐城224007 [5]哈尔滨医科大学心肌缺血教育部重点实验室,哈尔滨150086

出　　处：《肿瘤防治研究》2023年第9期913-918,共6页Cancer Research on Prevention and Treatment

基　　金：希思科-朝阳肿瘤研究基金(Y-Young2022-0188);美捷登青年科学家研究基金(MJR20220903);环境与健康教育部重点实验室开放课题(2022GWKFJJ01);机能与临床转化福建省高校重点实验室开放课题(XMMC-FCTM202205);江苏省肿瘤靶向纳米诊疗材料工程研究中心开放课题(JETNM202210)。

摘　　要：环状RNA(circRNA)参与肿瘤的进展已被频繁报道。circPVT1被证实是一种与多种肿瘤相关的癌基因,多项研究表明其在诸多肿瘤中异常表达,可调控肿瘤的恶性生物学行为,影响患者的生存预后。本文就circPVT1在肿瘤中的调控作用研究作一综述,以期对肿瘤的精准治疗提供参考。Circular RNA(circRNA)is involved in tumor progression.CircPVT1 is an oncogene that is abnormally expressed and correlated with a variety of tumors.It can regulate tumors’malignant behavior and affect the survival and prognosis of patients.This article reviews research on the regulatory roles of circPVT1 in tumors to provide references for accurate treatment.

关 键 词：CircPVT1 环状RNA 肿瘤 调控作用 

分 类 号：R730[医药卫生—肿瘤] Q52[医药卫生—临床医学]