杞菊地黄丸治疗睑板腺功能障碍所致蒸发过强型干眼症临床研究  

Clinical Study of Qiju Dihuang Pills for Evaporative Dry Eye Due to Meibomian Gland Dysfunction

作　　者：康泽林 陈虹 连曙光[1] KANG Zelin;CHEN Hong;LIAN Shuguang(Department of Ophthalmology,General Hospital of the Medical and Health Services Community of Shaoxing Second Hospital,Shaoxing Zhejiang 312000,China)

机构地区：[1]绍兴第二医院医共体总院眼科,浙江绍兴312000

出　　处：《新中医》2023年第14期29-32,共4页New Chinese Medicine

摘　　要：目的:观察杞菊地黄丸治疗睑板腺功能障碍(MGD)所致蒸发过强型干眼症的临床疗效。方法:将60例MGD所致蒸发过强型干眼症患者按照就诊顺序编号后,采用随机数字表法分为观察组和对照组各30例。对照组给予玻璃酸钠滴眼液治疗,观察组在对照组基础上给予杞菊地黄丸口服。2组疗程均为4周,观察比较2组临床疗效、症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SIT)水平。结果:观察组总有效率为93.33%,对照组为70.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组眼部症状评分比较,差异无统计学意义(P>0.05);治疗2、4周后,2组眼部症状评分均较治疗前降低(P<0.05),且观察组眼部症状评分在相同时间点均低于对照组(P<0.05)。治疗前,2组BUT、SIT水平比较,差异无统计学意义(P>0.05);治疗后,2组BUT、SIT水平均较治疗前升高(P<0.05),且观察组上述2项指标均高于对照组(P<0.05)。结论:杞菊地黄丸治疗MGD所致蒸发过强型干眼症可进一步提高临床疗效,增强泪膜稳定性,改善基础泪液分泌。Objective:To observe the clinical effect of Qiju Dihuang Pills for evaporative dry eye due to meibomian gland dysfunction(MGD).Methods:A total of 60 cases of patients with evaporative dry eye due to MGD were numbered according to their visit order and divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The control group was treated with Sodium Hyaluronate Eye Drops,and the observation group was additionally treated with the oral administration of Qiuju Dihuang Pills based on the treatment of the control group.The treatment course of both groups lasted for four weeks.Clinical effects,symptom scores,and the levels of tear break-up time(BUT)and Schirmer test(SIT)were observed and compared between the two groups.Results:The total effective rate was 93.33%in the observation group and 70.00%in the control group,the comparison between the two groups showed significance in the difference(P<0.05).Before treatment,there was no significant difference being found in the comparison of ocular symptom scores between the two groups(P>0.05).After two and four weeks of treatment,ocular symptom scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group at the same time points(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of BUT and SIT between the two groups(P>0.05).After treatment,the levels of BUT and SIT in the two groups were increased when compared with those before treatment(P<0.05),and the two indexes in the observation group were higher than those in the control group(P<0.05).Conclusions:Qiju Dihuang Pills for evaporative dry eye due to MGD can further improve clinical effects,and improve tear film stability and basal tear secretion.

关 键 词：干眼症 蒸发过强型 睑板腺功能障碍 杞菊地黄丸 泪膜破裂时间 泪液分泌试验 

分 类 号：R777.34[医药卫生—眼科]